Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo.
Objective: The objective of this study was to assess the potential of 3 spectroscopic techniques (intrinsic fluorescence, diffuse reflectance, and light scattering) individually and in combination (trimodal spectroscopy) for the detection of cervical squamous intraepithelial lesions.Study Design: Th...
| Published in: | American Journal of Obstetrics & Gynecology Vol. 186; no. 3; pp. 374 - 383 |
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| Main Authors: | , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Elsevier B.V.
Mar2002
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=6640550&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 6640550 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029378 AOG jtl: American Journal of Obstetrics & Gynecology issn: 00029378 maglogo: N pubinfo: dt: Mar2002 vid: 186 iid: 3 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 6640550 6640550 NLM11904594 6640550 10.1067/mob.2002.121075 NLM11904594 6640550 ppf: 374 ppct: 9 formats: tig: atl: Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo. aug: au: Georgakoudi, Irene Sheets, Ellen E. Müller, Markus G. Backman, Vadim Crum, Christopher P. Badizadegan, Kamran Dasari, Ramachandra R. Feld, Michael S. Müller, Markus G sug: subj: Cervix Neoplasms Diagnosis Spectrum Analysis Methods Precancerous Conditions Diagnosis Human Scattering, Radiation Light Diagnosis, Differential Female Validation Studies Comparative Studies Evaluation Research Multicenter Studies Female ab: Objective: The objective of this study was to assess the potential of 3 spectroscopic techniques (intrinsic fluorescence, diffuse reflectance, and light scattering) individually and in combination (trimodal spectroscopy) for the detection of cervical squamous intraepithelial lesions.Study Design: The study was conducted with 44 patients who underwent colposcopy for the evaluation of an abnormal Papanicolaou smear. Fluorescence and reflectance spectra were collected from colposcopically normal and abnormal sites and analyzed to extract quantitative information about tissue biochemistry and morphologic condition. This information was compared with histopathologic classification, and diagnostic algorithms were developed and validated with the use of logistic regression and cross-validation.Results: Diagnostically significant differences exist in the composition of fluorescing biochemicals, the scattering properties, and the epithelial cell nuclear morphology of cervical squamous intraepithelial lesions and non-squamous intraepithelial lesions. Trimodal spectroscopy is a superior tool for the detection of cervical squamous intraepithelial lesions than any 1 of the techniques alone.Conclusion: Trimodal spectroscopy has the potential to improve the in vivo detection of precancerous cervical changes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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