Helicobacter pylori and associated duodenal ulcer.
Twenty three children with coexistent duodenal ulcer and Helicobacter pylori infection were treated with either two weeks of amoxycillin (25 mg/kg/day) in addition to six weeks of cimetidine, or cimetidine alone. Endoscopy with antral and duodenal biopsies for urease test, microaerophilic culture, a...
| Publicado en: | Archives of Disease in Childhood Vol. 65; no. 11; pp. 1212 - 1217 |
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| Autores principales: | , , , , , , |
| Formato: | clinical trial research randomized controlled trial Journal Article |
| Publicado: |
BMJ Publishing Group
Nov1990
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=66707384&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 66707384 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039888 6PU jtl: Archives of Disease in Childhood issn: 00039888 maglogo: N pubinfo: dt: Nov1990 vid: 65 iid: 11 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 66707384 66707384 NLM2248531 66707384 10.1136/adc.65.11.1212 NLM2248531 66707384 ppf: 1212 ppct: 5 formats: tig: atl: Helicobacter pylori and associated duodenal ulcer. aug: au: Yeung, C. K. Fu, K. H. Yuen, K. Y. Ng, W. F. Tsang, T. M. Branicki, F. J. Saing, H. sug: subj: Helicobacter Pylori Helicobacter Infections Complications Duodenal Ulcer Microbiology Cimetidine Therapeutic Use Helicobacter Infections Drug Therapy Gastritis Microbiology Child, Preschool Child Recurrence Male Prospective Studies Adolescence Amoxicillin Therapeutic Use Duodenal Ulcer Drug Therapy Human Drug Therapy, Combination Female Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Male Female ab: Twenty three children with coexistent duodenal ulcer and Helicobacter pylori infection were treated with either two weeks of amoxycillin (25 mg/kg/day) in addition to six weeks of cimetidine, or cimetidine alone. Endoscopy with antral and duodenal biopsies for urease test, microaerophilic culture, and histological studies were performed at entry, six weeks, 12 weeks, and at six months. Children with persistent H pylori infection at six weeks were given a further two weeks' course of amoxycillin. H pylori persisted in all children not receiving amoxycillin treatment but cleared in six of the 13 children (46%) treated with amoxycillin. With failure of H pylori clearance at six months, only two out of six (33%) ulcers had healed and 50% of patients had experienced ulcer recurrence. In contrast, when H pylori remained cleared all ulcers healed and no ulcer recurred. Persistent H pylori infection was associated with persistent gastritis and duodenitis despite endoscopic evidence of ulcer healing. Detection and eradication of H pylori deserves particular attention in the routine management of duodenal ulceration in children. pubtype: Academic Journal doctype: clinical trial research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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