Lentigo Maligna: Melanoma In Situ on Chronically Sun-Damaged Skin.
Context.--Cutaneous primary invasive malignant melanoma often is classified by its histologic appearance. Major recognized histologic subtypes of melanoma include superficial spreading, lentigo maligna melanoma, nodular, and acral lentiginous. More recently, it has been shown that most primary invas...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 135; no. 7; pp. 838 - 842 |
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| Autores principales: | , |
| Formato: | pictorial Journal Article |
| Publicado: |
College of American Pathologists
Jul2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=66950699&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 66950699 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Jul2011 vid: 135 iid: 7 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 66950699 66950699 104637634 10.5858/2011-0051-rair.1 66950699 ppf: 838 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Lentigo Maligna: Melanoma In Situ on Chronically Sun-Damaged Skin. aug: au: Reed, Jon A. Shea, Christopher R. affil: Departments of Pathology and Dermatology, Baylor College of Medicine, Houston, Texas sug: subj: Skin Pathology Hutchinson's Melanotic Freckle Pathology Skin Neoplasms Pathology Sunlight Hutchinson's Melanotic Freckle Symptoms Immunohistochemistry Melanoma Classification ab: Context.--Cutaneous primary invasive malignant melanoma often is classified by its histologic appearance. Major recognized histologic subtypes of melanoma include superficial spreading, lentigo maligna melanoma, nodular, and acral lentiginous. More recently, it has been shown that most primary invasive melanomas harbor nonrandom genetic or biochemical aberrations that correlate with anatomic site or with the amount of cutaneous exposure to sunlight. It also is generally accepted that most primary invasive melanomas are preceded by an intraepidermal atypical melanocytic proliferation that lacks invasive capability (melanoma in situ). Objective.--To focus on lentigo maligna, the preinvasive/ in situ form of melanoma located on chronically sun-damaged skin. Data Sources.--Review of the literature and the authors' personal experiences. Conclusions.--A better understanding of the earliest stage of melanoma progression, including the contribution of chronic exposure to ultraviolet radiation, may lead to improved classification schemes that direct more effective targeted or personalized therapies for patients. pubtype: Academic Journal doctype: pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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