Anticoagulation prophylaxis practice patterns in patients having total hip, total knee replacement in a US health plan.
This study aims to illuminate anticoagulation prophylaxis practice patterns in the United States after total joint replacement surgery, with specific attention to duration of overlapping therapy for patients who are "bridged" from low-molecular-weight heparin (LMWH) to warfarin. A large hospital dru...
| Publicado en: | Formulary Vol. 46; no. 11; pp. 486 - 495 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MJH Life Sciences
Nov2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=67644598&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 67644598 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1082801X FRM jtl: Formulary issn: 1082801X maglogo: N pubinfo: dt: Nov2011 vid: 46 iid: 11 pid: 54670 pub: MJH Life Sciences place: Cranbury, New Jersey artinfo: ui: 67644598 67644598 108211575 67644598 ppf: 486 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Anticoagulation prophylaxis practice patterns in patients having total hip, total knee replacement in a US health plan. aug: au: Baser, Onur Wang, Li Supina, Dylan Sengupta, Nishan affil: Adjunct professor of internal medicine, University of Michigan sug: subj: Arthroplasty, Replacement, Knee Adverse Effects Arthroplasty, Replacement, Hip Adverse Effects Anticoagulants Therapeutic Use Venous Thromboembolism Prevention and Control Prescribing Patterns Funding Source Databases Billing and Claims Hospitals International Classification of Diseases Adult Male Female Human Middle Age Aged Aged, 80 and Over Severity of Illness Indices Treatment Outcomes Descriptive Statistics Poisson Distribution Incidence Data Analysis Software Anticoagulants Adverse Effects Retrospective Design Treatment Duration Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: This study aims to illuminate anticoagulation prophylaxis practice patterns in the United States after total joint replacement surgery, with specific attention to duration of overlapping therapy for patients who are "bridged" from low-molecular-weight heparin (LMWH) to warfarin. A large hospital drug database and linked outpatient files were retrospectively analyzed and compared for demographic, clinical, and provider characteristics. Of 2,280 enrollees, 1,770 met eligibility criteria, 1,551 received anticoagulant prophylaxis, 692 received only LMWH, and 595 received only warfarin. Of patients who were bridged from one agent to the other, 94% had less than 5 days of overlap. Each day of overlapping prophylaxis was associated with a 0.857 times decreased risk-adjusted incidence rate of thromboembolic events. Rates were 0.957 times lower for major bleeding and 0.895 times lower for minor bleeding for each day of overlap. In this analysis, longer duration of overlapping therapy is associated with decreased adverse event rates of both venous thromboembolism and bleeding. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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