Chemical constituents of Stereospermum acuminatissimum and their urease and α-chymotrypsin inhibitions
Abstract: Phytochemical investigation of the stem bark of Stereospermum acuminatissimum K. Schum. resulted in the isolation of 21 compounds, including two new guanine derivatives, 1,3,7-trimethylguanin-1/3-ium (1) and 3,7-dimethylguanin-1/3-ium (2), and one new phenolic long chain ester, 2-(4-hydrox...
| Publicado en: | Fitoterapia Vol. 83; no. 1; pp. 204 - 209 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jan2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=69738866&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 69738866 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Jan2012 vid: 83 iid: 1 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 69738866 104612880 104612880 10.1016/j.fitote.2011.10.014 69738866 ppf: 204 ppct: 5 formats: tig: atl: Chemical constituents of Stereospermum acuminatissimum and their urease and α-chymotrypsin inhibitions aug: au: Ramsay, Kamdem Soup T. Wafo, Pascal Ali, Zulfiqar Khan, Ajmal Oluyemisi, Ogbole O. Marasini, Bishnu P. Khan, Ikhlas A. Bonaventure, Ngadjui T. Choudhary, M. Iqbal Atta-ur-Rahman affil: Department of Organic Chemistry, Higher Teachers Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon sug: subj: Plants, Medicinal Plant Stems Plant Bark Plant Extracts Analysis Plant Extracts Pharmacodynamics Phytochemicals Analysis Enzyme Inhibitors Pharmacodynamics Alternative Therapies Chemistry, Physical Descriptive Statistics Urease Antagonists and Inhibitors Dose-Response Relationship, Drug ab: Abstract: Phytochemical investigation of the stem bark of Stereospermum acuminatissimum K. Schum. resulted in the isolation of 21 compounds, including two new guanine derivatives, 1,3,7-trimethylguanin-1/3-ium (1) and 3,7-dimethylguanin-1/3-ium (2), and one new phenolic long chain ester, 2-(4-hydroxyphenyl)ethyl hentriacontanoate (3). The known compounds were identified as sterequinones A, F, and H (4, 5, and 6), zenkequinones A-B (7–8), p-coumaric acid (9), methyl caffeate (10), caffeic acid (11), psilalic acid (12), syringaldehyde (13), norviburtinal (14), specioside (15), verminoside (16), tyrosol (17), eutigoside A (18), ellagic acid (19), atranorin (20), and ursolic acid (21). The metabolites were screened for their potential against urease and α-chymotrypsin enzymes, as urease is targeted in peptic ulcer while α-chymotrypsin is used to remove protein debris in ulcer. Compound 20 was found to be excellent urease inhibitor with IC50 value of 18.2±0.03μM. Compounds 13 and 18–20 are reported for the first time from the genus Stereospermum. The chemotaxonomic significance of the isolated compounds was also described. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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