Atypical Antipsychotic Drugs and Ethanol Withdrawal Syndrome: A Review.
Aims: Alcoholism and psychosis are known to have common neurochemical substrates. The aim of this review is to assess the reports involved in the effects of some atypical antipsychotic agents on the signs of ethanol withdrawal syndrome (EWS) in rats. Thus, both effectiveness of these drugs in ethano...
| Publicado en: | Alcohol & Alcoholism Vol. 47; no. 1; pp. 33 - 42 |
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| Autor principal: | |
| Formato: | research tables/charts Journal Article |
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Oxford University Press / USA
Jan/Feb2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=69899368&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 69899368 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jan/Feb2012 vid: 47 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 69899368 104614694 104614694 10.1093/alcalc/agr142 69899368 ppf: 33 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Atypical Antipsychotic Drugs and Ethanol Withdrawal Syndrome: A Review. aug: au: Uzbay, Tayfun I. affil: Gulhane Military Medical Academy, Faculty of Medicine, Department of Medical Pharmacology , Psychopharmacology Research Unit , Etlik, 06018 Ankara , Turkey sug: subj: Antipsychotic Agents Therapeutic Use Alcohol Withdrawal Syndrome Drug Therapy Ethanol Rats Models, Biological Clozapine Administration and Dosage Olanzapine Administration and Dosage Risperidone Administration and Dosage Quetiapine Administration and Dosage Ziprasidone Administration and Dosage Alcoholism Ethanol Administration and Dosage Ethanol Blood Human Funding Source ab: Aims: Alcoholism and psychosis are known to have common neurochemical substrates. The aim of this review is to assess the reports involved in the effects of some atypical antipsychotic agents on the signs of ethanol withdrawal syndrome (EWS) in rats. Thus, both effectiveness of these drugs in ethanol withdrawal and the association between the drug effects and the signs have been investigated here on the same animal model. Methods: Adult Wistar rats were used as subjects. Ethanol was given to rats by modified liquid diet technique for inducing ethanol dependence. Clozapine, olanzapine, risperidone, quetiapine and ziprasidone were the drugs tested. Effects of these drugs on the signs of ethanol withdrawal such as locomotor hyperactivity, stereotyped behavior, tremor, wet dog shakes, tail-stiffness, abnormal posture and gait, agitation and audiogenic seizures were evaluated for the first 6 h of ethanol withdrawal. Results: Although some beneficial effects of all the drugs on ethanol withdrawal signs were observed, olanzapine precipitated abnormal posture and gait in the animals. Effectiveness rank of the used atypical antipsychotics was as follows: risperidone = quetiapine > ziprasidone > klozapine > olanzapine. Conclusion: Our results suggest that risperidone and quetiapine seem to be potent and pharmacologically more active agents on EWS in rats. Thus, these drugs may be beneficial in treatment of EWS in patients with alcoholism. Ziprasidone and clozapine also seem to be useful drugs in treatment of ethanol withdrawal. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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