Omeprazole-amoxycillin therapy for eradication of Helicobacter pylori in duodenal ulcer bleeding: preliminary results of a pilot study.
Thirty-five patients with duodenal ulcer bleeding and Helicobacter pylori-colonization were assigned to receive 2 x 20 mg omeprazole and 3 x 750 mg amoxycillin daily for 2 weeks. Eradication was defined as no evidence of H. pylori infection by urease test and by histology 4 weeks after completion of...
| Publicado en: | Journal of Gastroenterology Vol. 30; no. 3; pp. 319 - 322 |
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| Autores principales: | , , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Springer Nature
Jun1995
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=71069007&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 71069007 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09441174 EJ7 jtl: Journal of Gastroenterology issn: 09441174 maglogo: N pubinfo: dt: Jun1995 vid: 30 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 71069007 71069007 NLM7647898 71069007 10.1007/BF02347506 NLM7647898 71069007 ppf: 319 ppct: 3 formats: tig: atl: Omeprazole-amoxycillin therapy for eradication of Helicobacter pylori in duodenal ulcer bleeding: preliminary results of a pilot study. aug: au: Jaspersen, Daniel Körner, Thomas Schorr, Wolfgang Brennenstuhl, Martin Carl-Heinz-Hammar Jaspersen, D Körner, T Schorr, W Brennenstuhl, M Hammar, C H affil: Division of Gastroenterology, Academic Medical Hospital, Pacelliallee 4-6 36043 Fulda Germany sug: subj: Omeprazole Therapeutic Use Peptic Ulcer Drug Therapy Amoxicillin Therapeutic Use Helicobacter Infections Drug Therapy Duodenal Ulcer Drug Therapy Pilot Studies Female Peptic Ulcer Microbiology Duodenal Ulcer Microbiology Amoxicillin Administration and Dosage Omeprazole Administration and Dosage Colony Count, Microbial Treatment Outcomes Aged, 80 and Over Helicobacter Pylori Helicobacter Pylori Drug Effects Human Helicobacter Infections Physiopathology Middle Age Male Adult Aged Drug Therapy, Combination Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female Male ab: Thirty-five patients with duodenal ulcer bleeding and Helicobacter pylori-colonization were assigned to receive 2 x 20 mg omeprazole and 3 x 750 mg amoxycillin daily for 2 weeks. Eradication was defined as no evidence of H. pylori infection by urease test and by histology 4 weeks after completion of therapy. Two patients were lost to follow up. All ulcers healed completely (100% ulcer healing rate). Twenty-nine out of the 33 patients were H. pylori-negative (87.9% eradication rate). Three patients complained of typical side effects of amoxycillin (9.1% side effect rate). The patients were prospectively followed for 12 months. After ulcer healing, no maintenance therapy was given. One of the 29 patients in whom H. pylori eradication had been successful suffered a second ulcer hemorrhage with H. pylori reinfection (3.4% relapse rate of ulcer bleeding), and this was managed endoscopically. Recurrent ulcer hemorrhage occurred in 2 out of 4 H. pylori-resistant patients. At the end of the follow-up period, of the patients in whom H. pylori eradication had been initially successful, only the patient with re-bleeding remained reinfected. The 4 H. pylori-resistant patients showed persistent H. pylori colonization. In conclusion, omeprazole plus amoxycillin is a safe and effective treatment for eradicating H. pylori; this treatment reduces the relapse rate of duodenal ulcer bleeding. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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