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Optimizing Cross-reactivity with Evolutionary Search for Sensors.

We report a straightforward evolutionary procedure to build an optimal sensor array from a pool of DNA sequences oriented toward three-way junctions. The individual sensors were mined from this pool under separate selection pressures to interact with four steroids, while allowing cross-reactivity, i...

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Publicado en:Journal of the American Chemical Society Vol. 134; no. 3; pp. 1642 - 1648
Autores principales: Kyung-Ae Yang, Renjun Pei, Stefanovic, Darko, Stojanovic, Milan N.
Formato: Artículo
Publicado: American Chemical Society 1/25/2012
Materias:
Oligonucleotide arrays
Detectors
Nucleotide sequence
Steroids
Hydrophobic compounds
Oligonucleotide synthesis
Acceso en línea:Ver este registro en EBSCOhost