Atypical Neural Processing of Ironic and Sincere Remarks in Children and Adolescents with Autism Spectrum Disorders.
Individuals with ASD show consistent impairment in processing pragmatic language when attention to multiple social cues (e.g., facial expression, tone of voice) is often needed to navigate social interactions. Building upon prior fMRI work examining how facial affect and prosodic cues are used to in...
| Publicado en: | Metaphor & Symbol Vol. 27; no. 1; pp. 70 - 93 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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Taylor & Francis Ltd
2012
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=71517063&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 71517063 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10926488 7MO jtl: Metaphor & Symbol issn: 10926488 maglogo: N pubinfo: dt: 2012 vid: 27 iid: 1 pid: 377 pub: Taylor & Francis Ltd artinfo: ui: 71517063 10.1080/10926488.2012.638856 ppf: 70 ppct: 23 formats: fmt: – @attributes: type: T db: hlh ui: 71517063 – @attributes: type: P db: hlh ui: 71517063 tig: atl: Atypical Neural Processing of Ironic and Sincere Remarks in Children and Adolescents with Autism Spectrum Disorders. aug: au: Colich, NatalieL. Wang, Audrey-Ting Rudie, JeffreyD. Hernandez, LeannaM. Bookheimer, SusanY. Dapretto, Mirella affil: University of California, Los Angeles, USA Mount Sinai School of Medicine su: Autism spectrum disorders Social perception Psychology Neurophysiology Brain function localization Children with autism spectrum disorders Language ability Irony Asperger's syndrome sug: subj: Autism spectrum disorders Social perception Psychology Neurophysiology Brain function localization Children with autism spectrum disorders Language ability Irony Asperger's syndrome ab: Individuals with ASD show consistent impairment in processing pragmatic language when attention to multiple social cues (e.g., facial expression, tone of voice) is often needed to navigate social interactions. Building upon prior fMRI work examining how facial affect and prosodic cues are used to infer a speaker's communicative intent, the authors examined whether children and adolescents with ASD differ from typically developing (TD) controls in their processing of sincere versus ironic remarks. At the behavioral level, children and adolescents with ASD and matched TD controls were able to determine whether a speaker's remark was sincere or ironic equally well, with both groups showing longer response times for ironic remarks. At the neural level, for both sincere and ironic scenarios, an extended cortical network—including canonical language areas in the left hemisphere and their right hemisphere counterparts—was activated in both groups, albeit to a lesser degree in the ASD sample. Despite overall similar patterns of activity observed for the two conditions in both groups, significant modulation of activity was detected when directly comparing sincere and ironic scenarios within and between groups. While both TD and ASD groups showed significantly greater activity in several nodes of this extended network when processing ironic versus sincere remarks, increased activity was largely confined to left language areas in TD controls, whereas the ASD sample showed a more bilateral activation profile which included both language and “theory of mind” areas (i.e., ventromedial prefrontal cortex). These findings suggest that, for high-functioning individuals with ASD, increased activity in right hemisphere homologues of language areas in the left hemisphere, as well as regions involved in social cognition, may reflect compensatory mechanisms supporting normative behavioral task performance. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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