Methodology to account for uncertainties and tradeoffs in pharmaceutical environmental hazard assessment
Many pharmaceutical products find their way into receiving waters, giving rise to concerns regarding their environmental impact. A procedure was proposed that enables ranking of the hazard to aquatic species and human health due to such products. In the procedure, hazard assessment is based on five...
| Publicado en: | Journal of Environmental Management Vol. 98; pp. 183 - 191 |
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| Autores principales: | , , , |
| Formato: | Artículo |
| Publicado: |
Academic Press Inc.
May2012
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=71802878&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 71802878 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 03014797 EMJ jtl: Journal of Environmental Management issn: 03014797 maglogo: N pubinfo: dt: May2012 vid: 98 pid: 735 pub: Academic Press Inc. artinfo: ui: 71802878 10.1016/j.jenvman.2012.01.001 ppf: 183 ppct: 8 formats: tig: atl: Methodology to account for uncertainties and tradeoffs in pharmaceutical environmental hazard assessment aug: au: Coutu, Sylvain Rossi, Luca Barry, D.A. Chèvre, Nathalie affil: Laboratoire de technologie écologique, Institut d’ingénierie de l’environnement, Faculté de l’environnement naturel, architectural et construit (ENAC), Station 2, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland IMG, Faculté de Géosciences and Environnement, Université de Lausanne, 1015 Lausanne, Switzerland su: Switzerland Drugs & the environment Environmental risk assessment Hazards Environmental toxicology research Drug analysis Physical & theoretical chemistry Effect of water pollution on aquatic organisms sug: subj: Switzerland Pharmaceuticals and pharmacy supplies merchant wholesalers Pharmaceutical and medicine manufacturing Drugs and Druggists' Sundries Merchant Wholesalers Drugs & the environment Environmental risk assessment Hazards Environmental toxicology research Drug analysis Physical & theoretical chemistry Effect of water pollution on aquatic organisms keyword: Environmental hazard Expert judgment Micropollutants Multi-criteria analysis Pharmaceuticals Environmental hazard Expert judgment Micropollutants Multi-criteria analysis Pharmaceuticals ab: Many pharmaceutical products find their way into receiving waters, giving rise to concerns regarding their environmental impact. A procedure was proposed that enables ranking of the hazard to aquatic species and human health due to such products. In the procedure, hazard assessment is based on five of the pharmaceutical product’s individual physico-chemical properties. These properties are aggregated using the weighted Euclidian distance as the utility function. The weights and physico-chemical properties are considered as random variables. Physico-chemical property uncertainty criteria are obtained from a literature review. Weight uncertainty is based on a hazard ranking from a panel of experts, the histogram of which is converted into a continuous probability density function using statistical Kernel smoothing technique. The hazard-ranking procedure was applied to a list of common pharmaceuticals used in Switzerland. The procedure is target-specific. Two rankings were presented: One giving priority to environmental protection and the other to human health. For most substances, the hazard rank depends on the target. For the Swiss case study, the ranking procedure led to the conclusion that the hormones ethinylestradiol and testosterone, along with the antibiotic erythromycin A, should be in all cases included in risk-assessment methodologies, environmental concentration estimates and regular measurement campaigns. The methodology proposed is flexible and can be extrapolated to other substances and groups of experts. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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