Rolling Circle Amplification-Templated DNA Nanotubes Show Increased Stability and Cell Penetration Ability.
DNA nanotubes hold promise as scaffolds for protein organization, as templates of nanowires and photonic systems, and as drug delivery vehicles. We present a new DNA-economic strategy for the construction of DNA nanotubes with a backbone produced by rolling circle amplification (RCA), which results...
| Publicado en: | Journal of the American Chemical Society Vol. 134; no. 6; pp. 2888 - 2892 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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American Chemical Society
2/15/2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=72319414&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 72319414 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 2/15/2012 vid: 134 iid: 6 pid: 997 pub: American Chemical Society artinfo: ui: 72319414 10.1021/ja2107492 ppf: 2888 ppct: 4 formats: tig: atl: Rolling Circle Amplification-Templated DNA Nanotubes Show Increased Stability and Cell Penetration Ability. aug: au: Hamblin, Graham D. Carneiro, Karma M. M. Fakhoury, Johans F. Bujold, Katherine E. Sleiman, Hanadi F. affil: Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 2K6 Canada su: DNA machinery Nanostructured materials synthesis Nanotubes Gene amplification Drug delivery devices Nucleic acid probes Imaging systems sug: subj: DNA machinery Nanostructured materials synthesis Nanotubes Gene amplification Drug delivery devices Nucleic acid probes Imaging systems ab: DNA nanotubes hold promise as scaffolds for protein organization, as templates of nanowires and photonic systems, and as drug delivery vehicles. We present a new DNA-economic strategy for the construction of DNA nanotubes with a backbone produced by rolling circle amplification (RCA), which results in increased stability and templated length. These nanotubes are more resistant to nuclease degradation, capable of entering human cervical cancer (HeLa) cells with significantly increased uptake over double-stranded DNA, and are amenable to encapsulation and release behavior. As such, they represent a potentially unique platform for the development of cell probes, drug delivery, and imaging tools. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2012 holdings: @attributes: islocal: N |
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