Controlled study in diabetic children comparing insulin-dosage adjustment by manual and computer algorithms.
A controlled trial of a new microprocessor device for insulin-dosage adjustment was undertaken in two matched groups of a priori well-controlled diabetic children. A prospective study design with three equal 8-wk periods was used. In the first period, both groups used manual methods for insulin-dosa...
| Publicado en: | Diabetes Care Vol. 13; no. 10; pp. 1080 - 1085 |
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| Autores principales: | , , , , , , , |
| Formato: | clinical trial research randomized controlled trial Journal Article |
| Publicado: |
American Diabetes Association
Oct1990
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=73207428&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 73207428 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01495992 1G7 jtl: Diabetes Care issn: 01495992 maglogo: N pubinfo: dt: Oct1990 vid: 13 iid: 10 pid: 1367 pub: American Diabetes Association place: Arlington, Virginia artinfo: ui: 73207428 73207428 NLM2209307 73207428 10.2337/diacare.13.10.1080 NLM2209307 73207428 ppf: 1080 ppct: 5 formats: tig: atl: Controlled study in diabetic children comparing insulin-dosage adjustment by manual and computer algorithms. aug: au: Chiarelli, Francesco Tumini, Stefano Morgese, Guido Albisser, A. Michael Chiarelli, F Tumini, S Morgese, G Albisser, A M affil: Department of Pediatrics, University of Chieti, Italy sug: subj: Insulin Administration and Dosage Algorithms Blood Glucose Self-Monitoring Drug Therapy, Computer Assisted Equipment and Supplies Diabetes Mellitus, Type 1 Drug Therapy Microcomputers Hypoglycemia Chemically Induced Female Child Human Insulin Adverse Effects Evaluation Research Prospective Studies Male Clinical Trials Validation Studies Comparative Studies Multicenter Studies Randomized Controlled Trials Child: 6-12 years Female Male ab: A controlled trial of a new microprocessor device for insulin-dosage adjustment was undertaken in two matched groups of a priori well-controlled diabetic children. A prospective study design with three equal 8-wk periods was used. In the first period, both groups used manual methods for insulin-dosage adjustment after manual criteria. In the second period, one group of children adjusted insulin dosage by computer algorithms, whereas the other continued to use manual methods. In the third period, both groups again adjusted insulin by traditional methods. Mean premeal glycemia and glycosylated hemoglobin levels did not change in either group throughout the study. During the second period, episodes of hypoglycemia were more frequent in children without the computer than in those who used the device. In keeping with the latter outcome, the group that used the microprocessor device was given less insulin in the second period than the first (0.88 +/- 0.02 vs. 0.94 +/- 0.02 U.kg-1.day-1, P less than 0.0001) and in comparison to the control group of patients who concurrently were given an increased insulin dose in the second period compared with the first. This study showed that insulin treatment through specific computer-mediated dosage-adjusting algorithms was safe and minimized hypoglycemia by effectively accommodating seasonally changing insulin requirements. We recommend the device to help diabetic children and their families in the care of insulin-dependent diabetes. pubtype: Academic Journal doctype: clinical trial research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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