DNA Computation: A Photochemically Controlled AND Gate.
DNA computation is an emerging field that enables the assembly of complex circuits based on defined DNA logic gates. DNA-based logic gates have previously been operated through purely chemical means, controlling logic operations through DNA strands or other biomolecules. Although gates can operate t...
| Publicado en: | Journal of the American Chemical Society Vol. 134; no. 8; pp. 3810 - 3816 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Chemical Society
2/29/2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=73342483&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 73342483 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 2/29/2012 vid: 134 iid: 8 pid: 997 pub: American Chemical Society artinfo: ui: 73342483 10.1021/ja210050s ppf: 3810 ppct: 6 formats: tig: atl: DNA Computation: A Photochemically Controlled AND Gate. aug: au: Prokup, Alex Hemphill, James Deiters, Alexander affil: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, United States su: Photochemical research Gate array circuits Molecular computers Electric circuits DNA sug: subj: Photochemical research Gate array circuits Molecular computers Electric circuits DNA ab: DNA computation is an emerging field that enables the assembly of complex circuits based on defined DNA logic gates. DNA-based logic gates have previously been operated through purely chemical means, controlling logic operations through DNA strands or other biomolecules. Although gates can operate through this manner, it limits temporal and spatial control of DNA-based logic operations. A photochemically controlled AND gate was developed through the incorporation of caged thymidine nucleotides into a DNA-based logic gate. By using light as the logic inputs, both spatial control and temporal control were achieved. In addition, design rules for light-regulated DNA logic gates were derived. A step-response, which can be found in a controller, was demonstrated. Photochemical inputs close the gap between DNA computation and silicon-based electrical circuitry, since light waves can be directly converted into electrical output signals and vice versa. This connection is important for the further development of an interface between DNA logic gates and electronic devices, enabling the connection of biological systems with electrical circuits. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2012 holdings: @attributes: islocal: N |
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