Epidemiology of Peptic Ulcer Disease: Endoscopic Results of a Systematic Investigation in Iran.
BACKGROUND Peptic ulcer disease is a multifactorial health problem affecting almost all populations worldwide. Large scale population-based studies are crucial to understanding its scope and specifications in various nations. We aimed to explore environmental risk factors of peptic ulcer disease in...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 4; no. 2; pp. 90 - 97 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=74435446&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 74435446 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Apr2012 vid: 4 iid: 2 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 74435446 74435446 104552904 74435446 ppf: 90 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Epidemiology of Peptic Ulcer Disease: Endoscopic Results of a Systematic Investigation in Iran. aug: au: Barazandeh, Farhad Yazdanbod, Abbas Pourfarzi, Farhad Ghajarieh Sepanlou, Sadaf Derakhshan, Mohammad H. Malekzadeh, Reza affil: Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran , Iran sug: subj: Peptic Ulcer Epidemiology Helicobacter Pylori Human Iran Endoscopy Methods Pearson's Correlation Coefficient Chi Square Test Fisher's Exact Test Data Analysis Software Logistic Regression Gastroesophageal Reflux Adult Middle Age Aged Aged, 80 and Over Male Female Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: BACKGROUND Peptic ulcer disease is a multifactorial health problem affecting almost all populations worldwide. Large scale population-based studies are crucial to understanding its scope and specifications in various nations. We aimed to explore environmental risk factors of peptic ulcer disease in the first population based study in Ardabil, Northwest Iran. METHODS This study was a part of a larger survey on upper gastrointestinal tract health conducted in Ardabil and Meshkinshahr with a total catchment area population of 600,000 persons during 2000-01. Using a random sampling proportional to place of residence, 1122 persons aged 40 or elder were selected. 1011 (90.1%) accepted participation and underwent a comprehensive medical examination and a systematic upper gastrointestinal endoscopy. Point prevalence of peptic ulcers was correlated to various life style risk factors. RESULTS Gastric and duodenal ulcers were identified in 33 (3.26%) and 50 (4.94%) participants, making an overall prevalence of 8.20%. Based on multivariable logistic regression analyses, H.pylori infection (OR 3.1, 95% CI: 2.1-4.7), Smoking (OR 1.8, 95% CI: 1.1-6.8), and chronic intake of NSAIDs (OR 2.8, 95% CI: 1.3-4.4) were main risk factors of gastric ulcer. For duodenal ulcer, in addition to H.pylori infection (OR 5.6, 95% CI: 1.9-8.8) and Smoking (OR 2.3, 95% CI: 1.4-6.5), male gender (OR 3.6, 95% CI: 1.2-5.8) and living in an urban area (OR 1.9, 95% CI: 1.1-5.2) were among significant risk factors. CONCLUSION This is the first population-based endoscopic study in North West of Iran reporting accurate point prevalence of peptic ulcer disease. The rate of 3.3% for gastric ulcer and 4.9% for duodenal ulcers are substantially lower than the estimates reported in Asian population-based endoscopic studies but higher than European reports. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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