Environmental Exposure to Polychlorinated Biphenyls and p,p′-DDE and Sperm Sex-Chromosome Disomy...dichlorodiphenyl-dichloroethylene
Background: Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention. Objectives: We evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p′-DDE) exposures with...
| Publicado en: | Environmental Health Perspectives Vol. 120; no. 4; pp. 535 - 541 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Apr2012
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=74530563&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 74530563 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Apr2012 vid: 120 iid: 4 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 74530563 104555498 104555498 10.1289/ehp.1104017 74530563 ppf: 535 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Environmental Exposure to Polychlorinated Biphenyls and p,p′-DDE and Sperm Sex-Chromosome Disomy...dichlorodiphenyl-dichloroethylene aug: au: McAuliffe, Megan E. Williams, Paige L. Korrick, Susan A. Altshul, Larisa M. Perry, Melissa J. affil: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA sug: subj: Environmental Exposure Epidemiology Polychlorinated Biphenyls Blood Hydrocarbons, Chlorinated Blood Sex Chromosome Aberrations Epidemiology Human Male Cross Sectional Studies In Situ Hybridization, Fluorescence Odds Ratio Adult Middle Age Massachusetts Self Report Questionnaires Semen Analysis Chromatography, Gas Data Analysis Software Spearman's Rank Correlation Coefficient Wilcoxon Rank Sum Test Descriptive Statistics Poisson Distribution Confidence Intervals Incidence Aneuploidy Chemically Induced Funding Source Sex Chromosome Aberrations Chemically Induced Adult: 19-44 years Middle Aged: 45-64 years Male ab: Background: Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention. Objectives: We evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p′-DDE) exposures with sperm sex-chromosome disomy. Methods: We conducted a cross-sectional study of 192 men from subfertile couples. We used multiprobe fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 57 PCB congeners and p,p′-DDE. Poisson regression models were used to calculate incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for demographic characteristics and semen parameters. Results: The median percent disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome disomy. We observed a significant trend of increasing IRRs for increasing quartiles of p,p′-DDE in XX, XY, and total sex-chromosome disomy, and a significant trend of increasing IRRs for increasing quartiles of PCBs for XY and total sex-chromosome disomy; however, there was a significant inverse association for XX disomy. Conclusions: Our findings suggest that exposure to p,p′-DDE may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to PCBs may be associated with increased rates of YY, XY, and total sex-chromosome disomy. In addition, we observed an inverse association between increased exposure to PCBs and XX disomy. Further work is needed to confirm these findings. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|