Repair and reconstruction of common bile duct by poly(lactide) stent.
To investigate the effect of repair of bioabsorbable poly(lactide) (PLA) biliary stent in common bile duct (CBD) transection injury in canine prior to the clinical application. Circular tubing CBD stent was prepared by melt extraction technique using PLA. A transection incision was made on CBD of th...
| Publicado en: | Revista CENIC Ciencias Quimicas Vol. 41; pp. 1 - 12 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
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Centro Nacional de Investigaciones Cientificas
2010 supplement
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| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=75018744&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 75018744 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 10158553 UF0 jtl: Revista CENIC Ciencias Quimicas issn: 10158553 maglogo: N pubinfo: dt: 2010 supplement vid: 41 pid: 21205 pub: Centro Nacional de Investigaciones Cientificas artinfo: ui: 75018744 ppf: 1 ppct: 11 formats: fmt: @attributes: type: P size: 386KB tig: atl: Repair and reconstruction of common bile duct by poly(lactide) stent. aug: au: Xiaoyi Xu Tongjun Liu Wei Jiang Zhen Shen Kai Zhang Yuxin Li Xiabin Jing affil: Cancer Center, First Hospital, Jilin University, Changchun Jilin 130024, China Department of General Surgery, Third Hospital, Jilin University, Changchun 130021, China Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China su: Surgical stents Bile ducts Biodegradation Polymers Biodegradable plastics Materials science Wounds & injuries sug: subj: Surgical stents Bile ducts Biodegradation Polymers Biodegradable plastics Materials science Wounds & injuries keyword: Biodegradable polymer Medical devices Poly(lactide) Dispositivos médicos Polímero biodegradable Poli (láctico) Stent biliar ab: To investigate the effect of repair of bioabsorbable poly(lactide) (PLA) biliary stent in common bile duct (CBD) transection injury in canine prior to the clinical application. Circular tubing CBD stent was prepared by melt extraction technique using PLA. A transection incision was made on CBD of the normal canine, and then closed the incision with laser welding followed the implantation of PLA tubular stent into it. The stent was obtained to determine degradation of PLA in vivo at postoperative week 1, 4, and 12, respectively. The changes of outer diameter and burst pressure of CBD were investigated. Furthermore, serum liver enzyme values and CBD histopathological analysis were examined in the animals. The results noted that the polymer stent exhibited the same biomedical functions as T tubes and no significant tissue response. Therefore, biodegradable PLA stent matches the requirements in repair and reconstruction of CBD to support the duct, guide bile drainage and reduce T-tube-related complications. Con el objetivo de investigar el efecto reparador de un stent biliar de ácido poli (láctico) bioabsorbable (PLA) se colocó en el conducto biliar común (CDB) en caninos previo a la aplicación clínica. Fue elaborado un stent circular CDB mediante la técnica de extracción por fusión empleando PLA. La incisión se realizó en la sección transversal del CDB sobre el canino normal y luego cerró la incisión mediante láser previa implantación de stent tubular de PLA en la cavidad. El stent se extrajo para determinar la degradación del PLA in vivo en las semanas postoperatorias 1, 4, y 12, respectivamente. Fueron investigados los cambios del diámetro exterior y la presión de ruptura de la CDB. Por otra parte, se examinaron en los animales los valores séricos de enzimas hepáticas y el análisis histopatológico del CDB. Los resultados mostraron que los stent de polímeros exhiben las mismas funciones biomédicas como tubos T observándose una respuesta favorable del tejido. Por lo tanto, los stent de PLA biodegradables presentan los requisitos necesarios para la reparación y la reconstrucción del CDB como apoyo del conducto, el drenaje de la bilis y como guía para reducir las complicaciones relacionadas con el tubo T. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista CENIC Ciencias Quimicas is the property of Centro Nacional de Investigaciones Cientificas and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista CENIC Ciencias Quimicas holder: Centro Nacional de Investigaciones Cientificas dt: @attributes: year: 2010 holdings: @attributes: islocal: N |
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