A Developmental Study of the Neural Circuitry Mediating Motor Inhibition in Bipolar Disorder.
Objective: Despite increased interest in the developmental trajectory of the pathophysiology mediating bipolar disorder, few studies have compared adults and youths with bipolar disorder. Deficits in motor inhibition are thought to play an important role in the pathophysiology of the illness across...
| Publicado en: | American Journal of Psychiatry Vol. 169; no. 6; pp. 633 - 642 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
American Psychiatric Publishing, Inc.
Jun2012
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=76549824&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 76549824 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: Jun2012 vid: 169 iid: 6 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 76549824 10.1176/appi.ajp.2012.11081244 ppf: 633 ppct: 9 formats: tig: atl: A Developmental Study of the Neural Circuitry Mediating Motor Inhibition in Bipolar Disorder. aug: au: Weathers, Judah D. Stringaris, Argyris Deveney, Christen M. Brotman, Melissa A. Zarate, Jr., Carlos A. Connolly, Megan E. Fromm, Stephen J. LeBourdais, Stephanie B. Pine, Daniel S. Leibenluft, Ellen affil: Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH, Bethesda, Md. Department of Adolescent Child Psychiatry, Institute of Psychiatry, King's College London, London Experimental Therapeutics and Pathophysiolog y Branch, Division of Intramural Research, NIMH, Bethesda, Md. Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, Bethesda, Md. Section on Development and Affective Neuroscience, Emotion and Development Branch, NIMH, Bethesda, Md. University of Massachusetts Medical School, Worcester, Mass. su: Bipolar disorder Pathological physiology Neural circuitry Magnetic resonance imaging Response inhibition sug: subj: Bipolar disorder Diagnostic Imaging Centers Pathological physiology Neural circuitry Magnetic resonance imaging Response inhibition ab: Objective: Despite increased interest in the developmental trajectory of the pathophysiology mediating bipolar disorder, few studies have compared adults and youths with bipolar disorder. Deficits in motor inhibition are thought to play an important role in the pathophysiology of the illness across the age spectrum. The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers. Method: Participants were pediatric (N=16) and adult (N=23) patients with bipolar disorder and healthy child (N=21) and adult (N=29) volunteers. Functional MRI (fMRI) data were acquired while participants performed the stop-signal task. Results: During failed inhibition, an age group-by-diagnosis interaction manifested in the anterior cingulate cortex, with bipolar youths exhibiting hypoactivation relative to both healthy youths and bipolar adults, and bipolar adults exhibiting hyperactivation relative to healthy adults. During successful inhibition, a main effect of diagnosis emerged in the right nucleus accumbens and the left ventral prefrontal cortex, with bipolar patients in both age groups showing less activation than healthy subjects. Conclusions: Anterior cingulate cortex dysfunction during failed motor inhibition was observed in both bipolar youths and adults, although the nature of this dysfunction differed between the two groups. Adults and youths with bipolar disorder exhibited similar deficits in activation of the nucleus accumbens and the ventral prefrontal cortex during success ful inhibition. Therefore, while subcortical and ventral prefrontal cortex hypoactivation was present in bipolar patients across the lifespan, anterior cingulate cortex dysfunction varied developmentally, with reduced activation in youths and increased activation in adults during failed inhibition. Longitudinal fMRI studies of the developmental trajectory of the neural circuitry mediating motor inhibition in bipolar disorder are warranted. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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