Specific Detection of Integrin α~β by Light-Up Bioprobe with Aggregation-Induced Emission Characteristics.
Specific bioprobes with fluorescence turn-on response are highly desirable for high contrast biosensing and imaging. In this work, we developed a new generation bioprobe by integrating tetraphenylsiole, a fluorogenic unit with aggregation-induced emission (AIE) characteristic, with cyclic arginine-g...
| Publicado en: | Journal of the American Chemical Society Vol. 134; no. 23; pp. 9569 - 9573 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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American Chemical Society
6/13/2012
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=77218813&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 77218813 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 6/13/2012 vid: 134 iid: 23 pid: 997 pub: American Chemical Society artinfo: ui: 77218813 10.1021/ja302369e ppf: 9569 ppct: 4 formats: tig: atl: Specific Detection of Integrin α~β by Light-Up Bioprobe with Aggregation-Induced Emission Characteristics. aug: au: Haibin Shi Jianzhao Liu Junlong Geng Ben Zhong Tang Bin Liu affil: Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117576, Singapore Department of Chemistry, Institute for Advanced Study, State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials, and Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China Institute of Materials Research and Engineering, 3 Research Link, 117602, Singapore su: Fluorescent probes Integrins Machine design Biosensors Ligands (Chemistry) Imaging systems Cancer cell analysis sug: subj: Fluorescent probes Integrins Machine design Biosensors Ligands (Chemistry) Imaging systems Cancer cell analysis ab: Specific bioprobes with fluorescence turn-on response are highly desirable for high contrast biosensing and imaging. In this work, we developed a new generation bioprobe by integrating tetraphenylsiole, a fluorogenic unit with aggregation-induced emission (AIE) characteristic, with cyclic arginine-glycine-aspartic acid tripeptide (cRGD), a targeting ligand to integrin αβ receptor. Emission of the AIE probe is switched on upon its specific binding to integrin αβ, which allows quantitative detection of integrin αβ, in solution and real-time imaging of the binding process between cRGD and integrin αβ on cell membrane. The probe can be used for tracking integrin αβ and for identifying integrin αβ-positive cancer cells. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2012 holdings: @attributes: islocal: N |
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