A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children.

Background: Nitric oxide (NO) is a mediator of immunity to malaria, and genetic polymorphisms in the promoter of the inducible NO synthase gene (NOS2) could modulate production of NO. We postulated that NOS2 promoter polymorphisms would affect resistance to severe malaria.Methods: We assessed genomi...

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Publicado en:	Lancet Vol. 360; no. 9344; pp. 1468 - 1476
Autores principales:	Hobbs, Maurine R, Udhayakumar, Venkatachalam, Levesque, Marc C, Booth, Jennifer, Roberts, Jacquelin M, Tkachuk, Ariana N, Pole, Ann, Coon, Hilary, Kariuki, Simon, Nahlen, Bernard L, Mwaikambo, Esther D, Lal, Altaf L, Granger, Donald L, Anstey, Nicholas M, Weinberg, J Brice
Formato:	research Journal Article
Publicado:	Lancet 11/9/2002
Acceso en línea:	Ver este registro en EBSCOhost