Wide-Open Flaps Are Key to Urease Activity.

Substrate ingress and product egress from the active site of urease is tightly controlled by an active site flap. Molecular dynamics simulations of urease have revealed a previously unobserved wide-open flap state that, unlike the well-characterized closed and open states, allows ready access to the...

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Publicado en:	Journal of the American Chemical Society Vol. 134; no. 24; pp. 9934 - 9938
Autores principales:	Roberts, Benjamin P., Miller, III, Bill R., Roitberg, Adrian E., Kenneth M. Merz, Jr.
Formato:	Artículo
Publicado:	American Chemical Society 6/20/2012
Materias:	Urease Binding sites Molecular dynamics Valence (Chemistry) Molecular structure
Acceso en línea:	Ver este registro en EBSCOhost