DRD2 C957T and TaqIA Genotyping Reveals Gender Effects and Unique Low-Risk and High-Risk Genotypes in Alcohol Dependence.
Aims: As recent conflicting reports describe a genetic association between both the C- and the T-alleles of the dopamine D2 receptor (DRD2) C957T polymorphism (rs6277) in alcohol-dependent subjects, our aim was to examine this polymorphism and TaqIA (rs1800497) in Australian alcohol-dependent subjec...
| Publicado en: | Alcohol & Alcoholism Vol. 47; no. 4; pp. 397 - 404 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jul/Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=77391879&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 77391879 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jul/Aug2012 vid: 47 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 77391879 104469557 104469557 10.1093/alcalc/ags047 77391879 ppf: 397 ppct: 7 formats: fmt: @attributes: type: P tig: atl: DRD2 C957T and TaqIA Genotyping Reveals Gender Effects and Unique Low-Risk and High-Risk Genotypes in Alcohol Dependence. aug: au: Swagell, Christopher D. Lawford, Bruce R. Hughes, Ian P. Voisey, Joanne Feeney, Gerald F.X. van Daal, Angela Connor, Jason P. Noble, Ernest P. Morris, C. Phillip Young, Ross McD. affil: Institute of Health and Biomedical Innovation , Queensland University of Technology , 60 Musk Ave., Kelvin Grove, Queensland 4059 , Australia sug: subj: Alcoholism Familial and Genetic Alcoholism Risk Factors Sex Factors Polymorphism, Genetic Genotype Alleles Human Funding Source Australia Male Female Adult Middle Age Aged Descriptive Statistics Odds Ratio Confidence Intervals Mantel-Haenszel Test Data Analysis Software P-Value Chi Square Test Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Aims: As recent conflicting reports describe a genetic association between both the C- and the T-alleles of the dopamine D2 receptor (DRD2) C957T polymorphism (rs6277) in alcohol-dependent subjects, our aim was to examine this polymorphism and TaqIA (rs1800497) in Australian alcohol-dependent subjects. Methods: The C957T polymorphism was genotyped in 228 patients with alcohol dependence (72 females and 156 males) and 228 healthy controls. Results: The C-allele and C/C genotype of C957T was associated with alcohol dependence, whereas the TaqIA polymorphism was not. When analysed separately for C957T, males showed an even stronger association with the C-allele and females showed no association. The C957T and TaqIA haplotyping revealed a strong association with alcohol dependence and a double-genotype analysis (combining C957T and TaqIA genotypes) revealed that the relative risk of different genotypes varied by up to 27-fold with the TT/A1A2 having an 8.5-fold lower risk of alcohol dependence than other genotypes. Conclusion: Decreased DRD2 binding associated with the C-allele of the DRD2 C957T polymorphism is likely to be important in the underlying pathophysiology of at least some forms of alcohol dependence, and this effect appears to be limited to males only. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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