Association of the Cocaine- and Amphetamine-Regulated Transcript Prepropeptide Gene (CARTPT) rs2239670 Variant with Obesity among Kampar Health Clinic Patrons, Malaysia.
Background: Cocaine- and amphetamine-regulated transcript (CART) is a hypothalamic anorectic neuropeptide that controls feeding behaviour and body weight. The study objective was to investigate the association of the CART prepropeptide gene (CARTPT) rs2239670 variant with obesity and its related ant...
| Publicado en: | Malaysian Journal of Medical Sciences Vol. 19; no. 1; pp. 43 - 52 |
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| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Malaysian Journal of Medical Sciences
Jan-Mar2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=77950211&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 77950211 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1394195X YQP jtl: Malaysian Journal of Medical Sciences issn: 1394195X maglogo: N pubinfo: dt: Jan-Mar2012 vid: 19 iid: 1 pid: 23493 pub: Malaysian Journal of Medical Sciences artinfo: ui: 77950211 77950211 104480665 77950211 ppf: 43 ppct: 9 formats: tig: atl: Association of the Cocaine- and Amphetamine-Regulated Transcript Prepropeptide Gene (CARTPT) rs2239670 Variant with Obesity among Kampar Health Clinic Patrons, Malaysia. aug: au: Yeo, Lisa Fan, Sook-Ha Say, Yee-How affil: Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman Perak Campus, 31900 Kampar, Perak, Malaysia sug: subj: Genetics Narcotics Obesity Human Malaysia Amphetamine Cocaine Anthropometry Polymorphism, Genetic Male Female Case Control Studies Genotype Logistic Regression Mutation Data Analysis Software Polymerase Chain Reaction Questionnaires Chi Square Test Analysis of Variance T-Tests Kruskal-Wallis Test Mann-Whitney U Test Descriptive Statistics Adult Middle Age Aged Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Cocaine- and amphetamine-regulated transcript (CART) is a hypothalamic anorectic neuropeptide that controls feeding behaviour and body weight. The study objective was to investigate the association of the CART prepropeptide gene (CARTPT) rs2239670 variant with obesity and its related anthropometric indicators among patients of a Malaysian health clinic in Kampar, Perak, Malaysia. Methods: A total of 300 Malay/Peninsular Bumiputera, Chinese, and Indian subjects (115 males, 185 females; 163 non-obese, 137 obese) were recruited by convenience sampling, and anthropometric measurements, blood pressures, and pulse rate were taken. Genotyping was performed using AvaII polymerase chain reaction-restriction fragment length polymorphism. Results: Genotyping revealed 203 (67.7%), 90 (30.0%), and 7 (2.3%) subjects with the GG, GA, and AA genotypes, respectively, with a minor allele (A) frequency of 0.17. No significant difference in the CARTPT rs2239670 genotype and allele distribution was found between obese and non-obese subjects, and logistic regression showed no association between the mutated genotypes (GA, AA) and allele (A) with obesity, even after adjusting for age, gender, and ethnicity. Furthermore, the measurements did not differ significantly between the genotypes and alleles. No significant difference in the genotype and allele distribution was found among genders, but they were significantly different among ethnicities (P = 0.030 and P = 0.019, respectively). Conclusion: CARTPT rs2239670 is not a predictor for obesity among the Malaysian subjects in this study. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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