Voluntary Running-Wheel Exercise Decreases the Threshold for Rewarding Intracranial Self-Stimulation.
Physical exercise has mood-enhancing and antidepressant properties although the mechanisms underly-ing these effects are not known. The present experiment investigated the effects of prolonged access to a running wheel on electrical self-stimulation of the lateral hypothalamus (LHSS), a measure of h...
| Publicado en: | Behavioral Neuroscience Vol. 126; no. 4; pp. 582 - 588 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=78276421&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 78276421 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: Aug2012 vid: 126 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 78276421 10.1037/a0029149 ppf: 582 ppct: 6 formats: tig: atl: Voluntary Running-Wheel Exercise Decreases the Threshold for Rewarding Intracranial Self-Stimulation. aug: au: Morris, Michael J. Na, Elisa S. Johnson, Alan Kim affil: Departments of Psychology, Health and Human Physiology and Pharmacology, and the Cardiovascular Center, University of Iowa, 11 Seashore Hall E, Iowa City, lA 52242-1407. su: Exercise & psychology Mental depression Brain stimulation Hypothalamus physiology Brain function localization Laboratory rats Anhedonia sug: subj: Exercise & psychology Mental depression All Other Animal Production Brain stimulation Hypothalamus physiology Brain function localization Laboratory rats Anhedonia keyword: anhedonia depression exercise intracranial self-stimulation reward anhedonia depression exercise intracranial self-stimulation reward ab: Physical exercise has mood-enhancing and antidepressant properties although the mechanisms underly-ing these effects are not known. The present experiment investigated the effects of prolonged access to a running wheel on electrical self-stimulation of the lateral hypothalamus (LHSS), a measure of hedonic state, in rats. Rats with continuous voluntary access to a running wheel for either 2 or 5 weeks exhibited dramatic leftward shifts in the effective current 50 (ECU50; current value that supports half of maximum responding) of their LHSS current-response functions compared to their baselines, indicating a decrease in reward threshold, whereas control rats current-response functions after 2 or 5 weeks were not significantly different from baseline. An inverse correlation existed between the change in ECU50 from baseline and the amount an animal had run in the day prior to LHSS testing, indicating that animals that exhibited higher levels of running showed a more robust decrease in LHSS threshold. We conclude that long-term voluntary exercise increases sensitivity to rewarding stimuli, which may contribute to its antidepressant properties. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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