A Comparison of the Effects of Temporary Hippocampal Lesions on Single and Dual Context Versions of the Olfactory Sequence Memory Task.
In recent years, many animal models of memory have focused on one or more of the various components of episodic memory. For example, the odor sequence memory task requires subjects to remember individual items and events (the odors) and the temporal aspects of the experience (the sequence of odor pr...
| Published in: | Behavioral Neuroscience Vol. 126; no. 4; pp. 588 - 593 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Published: |
American Psychological Association
Aug2012
|
| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=78276422&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 78276422 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: Aug2012 vid: 126 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 78276422 10.1037/a0028824 ppf: 588 ppct: 5 formats: tig: atl: A Comparison of the Effects of Temporary Hippocampal Lesions on Single and Dual Context Versions of the Olfactory Sequence Memory Task. aug: au: Sill, Orriana C. Smith, David M. affil: Department of Psychology, 252 Uris Hall, Cornell University, Ithaca, NY 14853. su: Memory Performance Hippocampus diseases Comparative studies Brain function localization Context effects (Psychology) Neurophysiology sug: subj: Memory Performance Hippocampus diseases Comparative studies Brain function localization Context effects (Psychology) Neurophysiology keyword: context episodic memory hippocampus sequence memory what-where-when context episodic memory hippocampus sequence memory what-where-when ab: In recent years, many animal models of memory have focused on one or more of the various components of episodic memory. For example, the odor sequence memory task requires subjects to remember individual items and events (the odors) and the temporal aspects of the experience (the sequence of odor presentation). The well-known spatial context coding function of the hippocampus, as exemplified by place cell firing, may reflect the "where" component of episodic memory. In the present study, we added a contextual component to the odor sequence memory task by training rats to choose the earlier odor in one context and the later odor in another context and we compared the effects of temporary hippocampal lesions on performance of the original single context task and the new dual context task. Temporary lesions significantly impaired the single context task, although performance remained significantly above chance levels. In contrast, performance dropped all the way to chance when temporary lesions were used in the dual context task. These results demonstrate that rats can learn a dual context version of the odor sequence learning task that requires the use of contextual information along with the requirement to remember the "what" and "when" components of the odor sequence. Moreover, the addition of the contextual component made the task fully dependent on die hippocampus. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|