Noradrenergic but Not Cholinergic Modulation of Olfactory Bulb During Processing of Near Threshold Concentration Stimuli.
Neuromodulatory systems such as noradrenaline (NE), acetylcholine (ACh), and serotonin (5HT) serve important functions in sensory perception. We use the olfactory bulb (OB) as a model system to study the roles of individual neuromodulators in sensory perception. Using a spontaneous, nonreward motiva...
| Publicado en: | Behavioral Neuroscience Vol. 126; no. 5; pp. 720 - 729 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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American Psychological Association
Oct2012
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=82394741&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 82394741 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: Oct2012 vid: 126 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 82394741 10.1037/a0030006 ppf: 720 ppct: 9 formats: tig: atl: Noradrenergic but Not Cholinergic Modulation of Olfactory Bulb During Processing of Near Threshold Concentration Stimuli. aug: au: Escanilla, Olga Alperin, Sam Youssef, Monica Ennis, Matthew Linster, Christiane affil: Computational Physiology Lab, Department of Neurobiology and Behavior, Cornell University; Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, University of Tennessee. su: Attention Discrimination (Sociology) Noradrenergic neurons Cholinergic mechanisms Olfactory bulb Brain stimulation Noradrenaline Brain function localization Signal-to-noise ratio sug: subj: Attention Discrimination (Sociology) Noradrenergic neurons Cholinergic mechanisms Olfactory bulb Brain stimulation Noradrenaline Brain function localization Signal-to-noise ratio keyword: acetylcholine neuromodulation noradrenaline olfaction olfactory bulb acetylcholine neuromodulation noradrenaline olfaction olfactory bulb ab: Neuromodulatory systems such as noradrenaline (NE), acetylcholine (ACh), and serotonin (5HT) serve important functions in sensory perception. We use the olfactory bulb (OB) as a model system to study the roles of individual neuromodulators in sensory perception. Using a spontaneous, nonreward motivated detection task, as well as a reward-motivated task, we show that rats can easily respond to odorants at very low concentrations when motivated to do so in a food-rewarded task, despite not showing spontaneous responses to these low concentration odorants. Using the same tasks paired with local bulbar infusions of noradrenergic and cholinergic drugs, we then show that rats engage their noradrenergic, but not their cholinergic system, to better respond to near threshold odorants. These results suggest that while cholinergic modulation of OB function is mostly important for odor decorrelation and discrimination, noradrenergic modulation is important for signal-to-noise modulation. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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