Investigating the neural correlates of goal-oriented upper extremity movements.
Objective:To understand neural correlates of upper extremity task performance (functional vs. non-functional) and to understand their influence on neuromotor control strategies. Design: Cross-sectional descriptive study, with repeated measures. Setting: Medical center 1.5T MRI clinical imaging facil...
| Published in: | NeuroRehabilitation Vol. 31; no. 4; pp. 421 - 429 |
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| Main Authors: | , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Sage Publications Inc.
2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=83849123&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 83849123 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10538135 3RE jtl: NeuroRehabilitation issn: 10538135 maglogo: N pubinfo: dt: 2012 vid: 31 iid: 4 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 83849123 83849123 104390764 10.3233/nre-2012-00812 83849123 ppf: 421 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Investigating the neural correlates of goal-oriented upper extremity movements. aug: au: Nathan, Dominic E. Prost, Robert W. Guastello, Stephen J. Jeutter And, Dean C. Reynolds, Norman C. affil: Department of Biomedical Engineering, Marquette University, Milwaukee, WI, USA sug: subj: Goals and Objectives Movement Upper Extremity Brain Physiology Human Magnetic Resonance Imaging Cross Sectional Studies Descriptive Research Analysis of Variance Male Female Adult Descriptive Statistics Questionnaires Data Analysis Software Two-Way Analysis of Variance Repeated Measures Adult: 19-44 years Male Female ab: Objective:To understand neural correlates of upper extremity task performance (functional vs. non-functional) and to understand their influence on neuromotor control strategies. Design: Cross-sectional descriptive study, with repeated measures. Setting: Medical center 1.5T MRI clinical imaging facility. Participants: Neurologically intact individuals, (M=14 F=5 mean age=22.94 ± 3.1 years) all right hand dominant as determined by the Edinburgh handedness survey. Subjects performed upper extremity motor tasks of reaching and grasping in a block paradigm. Whole brain fMRI data was acquired using a 1.5T MRI scanner. Main outcome measures: Differences in fMRI area of activation and maximum activation intensity for the whole brain were evaluated among the different upper extremity motor tasks. Results: Our results indicate (a) Activations in brain regions are task specific. (b) ANOVA results indicate functional goal oriented movements of reaching and grasping produce higher activation intensity (p < 0.0001) in more regions of the cortex (Somatosensory motor area, primary motor cortex, and parietal region) and cerebellum (p < 0.001) as compared to nonfunctional rhythmic movements of reaching only and grasping only. (c) There is some overlap in cerebellar activations, however areas of activation in the medial cerebellum were observed for reaching-and-grasping, while the grasping-only task produced activation more laterally in the cerebellum. Conclusions: Our findings suggest that (a) neuromotor strategy for functional goal-oriented movements is different from rhythmic movements such as finger tapping or non-functional movements, (b) This difference can be quantified and mapped using fMRI. (c) There are some overlap with activation of movement execution however the cognitive component that mediates the specific movement is not just the linear combination of simple movements rather it is task and context specific. (d) The results support the concept of using goal-oriented tasks in the applications of rehabilitation and therapy for restoration of function. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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