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Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region.

Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with...

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Publicado en:Revista Iberoamericana de Micologia Vol. 29; no. 4; pp. 210 - 214
Autores principales: Debourgogne, Anne, Hagen, Ferry, Elenga, Narcisse, Long, Laurence, Blanchet, Denis, Veron, Vincent, Lortholary, Olivier, Carme, Bernard, Aznar, Christine
Formato: Artículo
Publicado: Elsevier B.V. 10/31/2012
Materias:
Infection treatment
Cryptococcosis
Neurosurgery
Juvenile diseases
Amphotericin B
Disease incidence
Comparative studies
French Guiana
Acceso en línea:Ver este registro en EBSCOhost
Sumario:Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.
Comparado con la incidencia en pacientes adultos, la criptococosis es una infección excepcional entre niños. Describimos un caso de neurocriptococosis debida a Cryptococcus gattii en una niña de 5 años de edad, sin factores de riesgo identificados, que vivía en la Guyana francesa. La cirugía neurológica combinada con un tratamiento antimicótico prolongado con anfotericina B y flucitosina (5-fluorocitosina) resolvieron satisfactoriamente la infección. La caracterización molecular posterior del aislamiento de Cryptococcus reveló que la infección se debió al genotipo AFLP6B/cepa VGIIb de C. gattii.