Pulmonary Function Impairment May Be an Early Risk Factor for Late-Life Cognitive Impairment.
Objectives To determine the association between change in pulmonary function ( PF) and mid- and late-life cognitive function. Design Prospective population-based cohort study that included measures of pulmonary function in midlife and brain magnetic resonance imaging data acquired in late life. Sett...
| Publicado en: | Journal of the American Geriatrics Society Vol. 61; no. 1; pp. 79 - 84 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Wiley-Blackwell
Jan2013
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=84740613&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 84740613 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00028614 20Q jtl: Journal of the American Geriatrics Society issn: 00028614 maglogo: Y pubinfo: dt: Jan2013 vid: 61 iid: 1 pid: 480 pub: Wiley-Blackwell artinfo: ui: 84740613 10.1111/jgs.12069 ppf: 79 ppct: 5 formats: tig: atl: Pulmonary Function Impairment May Be an Early Risk Factor for Late-Life Cognitive Impairment. aug: au: Vidal, Jean‐Sébastien Aspelund, Thor Jonsdottir, Maria K. Jonsson, Palmi V. Harris, Tamara B. Lopez, Oscar L. Gudnason, Vilmundur Launer, Lenore J. affil: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging National Institutes of Health, Bethesda Maryland Geriatrics Department, Assistance Publique Hopitaux de Paris, Broca Hospital, Paris France Icelandic Heart Association, Kopavogur Iceland Faculty of Psychology, University of Iceland, Reykjavik Iceland Faculty of Medicine, University of Iceland, Reykjavik Iceland Geriatric Research Center, Landspitali University Hospital, Reykjavik Iceland Department of Psychiatry, University of Pittsburgh, Pittsburgh Pennsylvania Department of Neurology, University of Pittsburgh, Pittsburgh Pennsylvania su: Iceland Epidemiology Psychological tests Self-evaluation Cognition disorder risk factors Confidence intervals Longitudinal method Lung diseases Regression analysis Research funding Pulmonary function tests Logistic regression analysis Data analysis Vital capacity (Respiration) Geriatric Depression Scale Data analysis software Descriptive statistics Disease complications sug: subj: Epidemiology Psychological tests Self-evaluation Iceland Cognition disorder risk factors Confidence intervals Longitudinal method Lung diseases Regression analysis Research funding Pulmonary function tests Logistic regression analysis Data analysis Vital capacity (Respiration) Geriatric Depression Scale Data analysis software Descriptive statistics Disease complications keyword: cognition dementia forced expiratory volume longitudinal cohort studies cognition dementia forced expiratory volume longitudinal cohort studies ab: Objectives To determine the association between change in pulmonary function ( PF) and mid- and late-life cognitive function. Design Prospective population-based cohort study that included measures of pulmonary function in midlife and brain magnetic resonance imaging data acquired in late life. Setting The Age, Gene/Environment Susceptibility-Reykjavik Study. Participants Three thousand six hundred sixty-five subjects who had at least one measure of forced expiratory volume in 1 second ( FEV) and were cognitively tested on average 23 years later. A subset of 1,281 subjects had two or three measures of FEV acquired over a 7.8-year period. Measurements Pulmonary function was estimated as FEV/height. Rate of PF decline was estimated as the slope of decline over time. Cognitive status was measured with continuous scores of memory, speed of processing, and executive function and as the outcome of mild cognitive impairment ( MCI) and dementia. Results Lower PF measured in midlife predicted poorer memory, slower speed of processing, poorer executive function, and greater likelihood of MCI and dementia 23 years later. Decrease in PF over a 7.8-year period in midlife was not associated with MCI or dementia. Conclusion Low PF measured in midlife may be an early marker of later cognitive problems. Additional studies characterizing early and late PF changes are needed. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|