Reduced Prefrontal Hemodynamic Response in Pediatric Obsessive-Compulsive Disorder as Measured by Near-Infrared Spectroscopy.
Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. Functional neuroimaging studies of patients with obsessive-compulsive disorder (OCD) have suggested that the frontal cortex and subcortical structures may pla...
| Publicado en: | Child Psychiatry & Human Development Vol. 44; no. 2; pp. 265 - 278 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Springer Nature
Apr2013
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=86177273&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 86177273 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0009398X CPH jtl: Child Psychiatry & Human Development issn: 0009398X maglogo: N pubinfo: dt: Apr2013 vid: 44 iid: 2 pid: 237 pub: Springer Nature artinfo: ui: 86177273 10.1007/s10578-012-0323-0 ppf: 265 ppct: 13 formats: fmt: @attributes: type: P size: 388KB tig: atl: Reduced Prefrontal Hemodynamic Response in Pediatric Obsessive-Compulsive Disorder as Measured by Near-Infrared Spectroscopy. aug: au: Ota, Toyosaku Iida, Junzo Sawada, Masayuki Suehiro, Yuko Yamamuro, Kazuhiko Matsuura, Hiroki Tanaka, Shohei Kishimoto, Naoko Negoro, Hideki Kishimoto, Toshifumi affil: Department of Psychiatry, Nara Medical University, 840 Shijyou-cho Kashihara-shi 634-8522 Japan Faculty of Nursing, Nara Medical University, Kashihara-shi Japan Department of Psychiatry, Hannan Hospital, Sakai-shi Japan Department of Education, Nara University of Education, Nara-shi Japan su: Therapeutics Near infrared spectroscopy Psychiatric diagnosis research Brain function localization Obsessive-compulsive disorder in children Prefrontal cortex Pathological physiology sug: subj: Therapeutics Near infrared spectroscopy Psychiatric diagnosis research Brain function localization Obsessive-compulsive disorder in children Prefrontal cortex Pathological physiology keyword: Functional neuroimaging study Near-infrared spectroscopy Pediatric obsessive-compulsive disorder Prefrontal hemodynamic response Functional neuroimaging study Near-infrared spectroscopy Pediatric obsessive-compulsive disorder Prefrontal hemodynamic response ab: Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. Functional neuroimaging studies of patients with obsessive-compulsive disorder (OCD) have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of the disorder. Twelve treatment-naïve children with OCD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s during the Stroop color-word task, using 24-channel NIRS machines. During the Stroop color-word task, the oxy-Hb changes in the OCD group were significantly smaller than those in the control group in the prefrontal cortex, especially in the frontopolar cortex. The present study suggests that children with OCD have reduced prefrontal hemodynamic response as measured by NIRS. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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