Fucoidan Inhibited 4T1 Mouse Breast Cancer Cell Growth In Vivo and In Vitro Via Downregulation of Wnt/β-Catenin Signaling.
Fucoidan is a sulfated polysaccharide derived from brown algae and is known to possess anticancer properties. However, the relationship between fucoidan and β-catenin, one of the key components of the Wnt signaling pathway, in mouse breast cancer remains poorly characterized. In this study, mouse br...
| Publicado en: | Nutrition & Cancer Vol. 65; no. 3; pp. 460 - 469 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
Apr2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=86409267&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 86409267 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Apr2013 vid: 65 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 86409267 104258694 104258694 10.1080/01635581.2013.757628 86409267 ppf: 460 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Fucoidan Inhibited 4T1 Mouse Breast Cancer Cell Growth In Vivo and In Vitro Via Downregulation of Wnt/β-Catenin Signaling. aug: au: Xue, Meilan Ge, Yinlin Zhang, Jinyu Liu, Yongchao Wang, Qing Hou, Lin Zheng, Zheng affil: Department of Biochemistry and Molecular Biology, Medical College, Qingdao University, Qingdao, Shandong Province, China sug: subj: Cell Physiology Nutrition Animal Studies Mice In Vivo Studies In Vitro Studies Cell Cycle Blotting, Western Biological Assay Immunohistochemistry Data Analysis Descriptive Statistics T-Tests ab: Fucoidan is a sulfated polysaccharide derived from brown algae and is known to possess anticancer properties. However, the relationship between fucoidan and β-catenin, one of the key components of the Wnt signaling pathway, in mouse breast cancer remains poorly characterized. In this study, mouse breast cancer cells (4T1) were exposed to fucoidan to investigate the relationship between fucoidan and the Wnt/β-catenin signaling pathway in vivo and in vitro. We found that fucoidan significantly inhibited cell growth, increased cell death, and induced G1 cell cycle arrest in 4T1 cells. Fucoidan also reduced β-catenin expression and T cell factor/lymphoid-enhancing factor reporter activity. Furthermore, fucoidan downregulated the expression of downstream target genes such as c-myc, cyclin D1, and survivin. Intraperitoneal injection of fucoidan in tumor-bearing mice reduced the tumor volume and weight. Fucoidan induced aberrant downregulation of β-catenin in tumor tissues with a significant increase in apoptosis. Thus, our data suggested that fucoidan exerts its anticancer activity through downregulation of Wnt/β-catenin signaling. Fucoidan may be an effective therapy for the chemoprevention and treatment of mouse breast cancer. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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