Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management.
Antiphospholipid syndrome is a relatively recent systemic autoimmune disorder defined by thrombotic events and/or obstetric complications in the presence of persistent elevated antiphospholipid antibodies. It is characterized by a wide spectrum of clinical presentations and virtually any organ syste...
| Publicado en: | Acta Reumatológica Portuguesa Vol. 38; no. 1; pp. 10 - 19 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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Sociedade Portuguesa de Reumatologia
jan-mar2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=87118293&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 87118293 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 0303464X 4Z1D jtl: Acta Reumatológica Portuguesa issn: 0303464X maglogo: N pubinfo: dt: jan-mar2013 vid: 38 iid: 1 pid: 38819 pub: Sociedade Portuguesa de Reumatologia artinfo: ui: 87118293 ppf: 10 ppct: 9 formats: fmt: @attributes: type: P size: 8.2MB tig: atl: Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management. aug: au: Pinto-Almeida, Teresa Caetano, Mónica Sanches, Madalena Selores, Manuela affil: Serviço de Dermatologia, Hospital de Santo António - Centro Hospitalar do Porto, Porto, Portugal Instituto de Ciências Biomédicas Abel Salazar - Universidade de Porto, Porto, Portugal su: Skin diseases Antiphospholipid syndrome treatment Antiphospholipid syndrome Autoimmune diseases Obstetrics Biological nomenclature Dermatology Diagnosis sug: subj: Skin diseases Antiphospholipid syndrome treatment Antiphospholipid syndrome Autoimmune diseases Obstetrics Biological nomenclature Dermatology Diagnosis keyword: Antiphospholipid Syndrome Dermatologia Diagnóstico Pele Review Revisão Síndrome Antifosfolipidico Skin Dermatologia Diagnóstico Pele Revisão Síndrome Antifosfolipidico ab: Antiphospholipid syndrome is a relatively recent systemic autoimmune disorder defined by thrombotic events and/or obstetric complications in the presence of persistent elevated antiphospholipid antibodies. It is characterized by a wide spectrum of clinical presentations and virtually any organ system or tissue may be affected by the consequences of vascular occlusion. Diagnosis is sometimes difficult and although classification criteria have been published and revised there remain ongoing issues regarding nomenclature, expanding clinical features, laboratory tests and management and much still has to be done. Cutaneous manifestations are common and frequently the first sign of the disease. Although extremely diverse it's important to know which dermatological findings should prompt consideration of antiphospholipid syndrome and the appropriate management for those patients. Much has been debated about when to consider antiphospholipid syndrome and consensus still does not exist, however in spite of being a diagnostic challenge clinicians should know when to look for antiphospholipid antibodies since an early diagnosis is important to prevent further and serious complications. In this article we focus on the cutaneous features that should raise suspicion on the presence of antiphospholipid syndrome and on the complex management of such patients. Many other dermatological signs related to this syndrome have been described in the literature but only occasionally and without consistency or statistic impact and therefore will not be considered here. O síndrome antifosfolipidico é uma patologia auto-imu-ne relativamente recente definida por eventos trombó-ticos e/ou complicações obstétricas na presença de anticorpos antifosfolípido elevados persistentes. Caracteriza-se por um vasto leque de apresentações clínicas e virtualmente qualquer sistema orgânico ou tecido pode ser afectado por oclusão vascular. 0 diagnóstico é por vezes difícil e, apesar de critérios de classificação terem sido publicados e revistos, muitas dúvidas persistem relativamente à nomenclatura, características clínicas, testes laboratoriais e abordagem destes doentes. As manifestações cutâneas são comuns e, frequentemente, o primeiro sinal da doença. Apesar da grande variabilidade, é importante reconhecer os achados dermatológicos que devem levantar a suspeita de um síndrome antifosfolipidico, assim como a abordagem adequada destes doentes. Muito tem sido debatido sobre quando considerar o diagnóstico desta entidade, não havendo ainda consenso neste assunto; no entanto, apesar de ser um desafio diagnóstico, é importante saber quando investigar a presença de anticorpos antifosfolípidos, uma vez que um diagnóstico precoce é crucial para prevenir complicações futuras graves. No presente artigo os autores descrevem as manifestações dermatológicas que devem fazer considerar o diagnóstico com enfoque na abordagem complexa destes doentes. Têm sido descritas na literatura muitas outras alterações cutâneas relacionadas com esta entidade, no entanto, apenas de forma ocasional e sem consistência ou impacto estatístico, pelo que não serão consideradas. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Acta Reumatológica Portuguesa is the property of Sociedade Portuguesa de Reumatologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Acta Reumatológica Portuguesa holder: Sociedade Portuguesa de Reumatologia dt: @attributes: year: 2013 holdings: @attributes: islocal: N |
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