Calcium bioavailability of calcium L-threonate in healthy Chinese subjects measured with stable isotopes (Ca and Ca).
Purpose: Calcium L-threonate is a novel drug that was developed for the treatment of osteoporosis and as a calcium supplement. However, calcium bioavailability of this drug is unknown due to lack of effective evaluation methods. In this study, we sought to measure the bioavailability of calcium L-th...
| Published in: | European Journal of Clinical Pharmacology Vol. 69; no. 5; pp. 1121 - 1127 |
|---|---|
| Main Authors: | , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Springer Nature
May2013
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=87390953&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 87390953 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: May2013 vid: 69 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 87390953 104281603 104281603 10.1007/s00228-012-1420-5 87390953 ppf: 1121 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Calcium bioavailability of calcium L-threonate in healthy Chinese subjects measured with stable isotopes (Ca and Ca). aug: au: Wang, Hongyun Hu, Pei Jiang, Ji affil: Clinical Pharmacology Research Center, Peking Union Medical College Hospital, No.1 Shuai FuYuan, Dong Cheng District Beijing 100730 People's Republic of China sug: subj: Calcium Administration and Dosage Injections, Intravenous Methods Osteoporosis Drug Therapy Biological Availability Isotopes Human China Male Female Adult Descriptive Statistics Data Analysis Software Pharmacokinetics Pearson's Correlation Coefficient T-Tests Electrocardiography Funding Source Adult: 19-44 years Male Female ab: Purpose: Calcium L-threonate is a novel drug that was developed for the treatment of osteoporosis and as a calcium supplement. However, calcium bioavailability of this drug is unknown due to lack of effective evaluation methods. In this study, we sought to measure the bioavailability of calcium L-threonate with a double-label stable isotope method. Methods: Fourteen healthy Chinese subjects were enrolled in the clinical study and were given 300 mg calcium L-threonate tablets containing 40 mg Ca after an intravenous injection of 4 mg Ca solution (as calcium chloride). Fractional urine samples were collected at the following time intervals: 0-3, 3-6, 6-9, 9-13, 13-24, 24-36 and 36-48 h. The abundance ratios of Ca/Ca and Ca/Ca in the urine were determined with thermal-ionization mass spectrometry (TI-MS). The calcium bioavailability was estimated by calculating the true fractional calcium absorption (TFCA) using the abundance ratios of Ca/Ca and Ca/Ca. Results: The bioavailability of calcium L-threonate in 14 healthy Chinese subjects was 26.49 ± 9.39 %. There was good agreement between TFCA from the 24 to 36 h and the 36 to 48 h urine pool, indicating that calcium balance was achieved at 24 h after dosing. The TFCA of the subjects did not statistically correlate with total urinary calcium excretion (0-48 h). There were no serious adverse events in this study. Conclusions: The bioavailability of calcium L-threonate in humans was successfully determined by estimating TFCA with the double-label stable isotope method, thus providing a useful approach for the evaluation of bioavailability of calcium formulations. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|