A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer.
Background: Aurora A kinase, a centrosomal serine/threonine kinase which plays an essential role in chromosome segregation during cell division, is commonly amplified and/or over expressed in human malignancies. Aurora A is suggested to be one of the proliferation parameters which is an independent...
| Publicado en: | BMC Cancer Vol. 13; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=88981364&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 88981364 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712407 1CH9 jtl: BMC Cancer issn: 14712407 maglogo: N pubinfo: dt: 2013 vid: 13 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 88981364 88981364 NLM23627634 10.1186/1471-2407-13-217 NLM23627634 88981364 ppf: 1 ppct: 10 formats: tig: atl: A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer. aug: au: Yamamoto, Satoko Yamamoto-Ibusuki, Mutsuko Yamamoto, Yutaka Fujiwara, Saori Iwase, Hirotaka affil: Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo Kumamoto, Kumamoto 860-8556, Japan sug: subj: Cell Physiology Transferases Breast Neoplasms Metabolism Polymerase Chain Reaction Immunohistochemistry Kaplan-Meier Estimator Prognosis Transferases Analysis Breast Neoplasms Mortality Female Gene Expression Profiling Genotype Cox Proportional Hazards Model Breast Neoplasms Pathology Reverse Transcriptase Polymerase Chain Reaction Scales Female ab: Background: Aurora A kinase, a centrosomal serine/threonine kinase which plays an essential role in chromosome segregation during cell division, is commonly amplified and/or over expressed in human malignancies. Aurora A is suggested to be one of the proliferation parameters which is an independent prognostic factor for early invasive breast cancer patients; however the individual clinical or prognostic relevance of this gene has been a matter of debate.Methods: A comprehensive analysis of Aurora A at the levels of gene expression, gene copy number and protein expression was performed for 278 primary invasive breast cancer patients; and the correlation with clinical outcomes were investigated.Results: Aurora A gene expression level not only correlated with gene amplification, but was also significantly associated with several clinicopathological parameters and patient prognosis. Patients with higher nuclear grade, negative progesterone receptor status and higher Ki67 expressed higher levels of Aurora A mRNA, which was associated not only with poor relapse-free survival (RFS) but was also found to be a significant multivariate parameter for RFS. Aurora A protein expression was also significantly associated with clinicopathological characteristics; lymph node status, nuclear grade, estrogen receptor status and Ki67, but not with prognosis. By contrast, Aurora A gene amplification correlated with tumor size, nuclear grade and Ki67, and had no prognostic value.Conclusion: Our data indicate that Aurora A gene expression is an effective tool, which defines both tumor proliferation potency and patient prognosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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