Bone Marrow Examination for Unexplained Cytopenias Reveals Nonspecific Findings in Patients With Collagen Vascular Disease.
Context.-Collagen vascular diseases are frequently included in the differential diagnosis for unexplained cytopenias and often prompt a bone marrow biopsy in this patient population to exclude malignancy. Few large-scale studies have characterized the bone marrow morphology in patients with collagen...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 137; no. 7; pp. 948 - 955 |
|---|---|
| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Jul2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=89240831&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 89240831 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Jul2013 vid: 137 iid: 7 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 89240831 104200697 104200697 10.5858/arpa.2011-0603-OA 89240831 ppf: 948 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Bone Marrow Examination for Unexplained Cytopenias Reveals Nonspecific Findings in Patients With Collagen Vascular Disease. aug: au: Hunt, Kristin E. Salama, Mohamed E. Sever, Cordelia E. Foucar, Kathryn affil: Department of Pathology & Laboratory Medicine, Henry Ford Hospital, Detroit, MI sug: subj: Bone Marrow Examination Hematologic Diseases Diagnosis Connective Tissue Diseases Diagnosis Blood Cell Count Bone Marrow Pathology Immunohistochemistry Comparative Studies Prospective Studies Analysis of Variance Chi Square Test Adult Middle Age Aged Aged, 80 and Over Female Male Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Context.-Collagen vascular diseases are frequently included in the differential diagnosis for unexplained cytopenias and often prompt a bone marrow biopsy in this patient population to exclude malignancy. Few large-scale studies have characterized the bone marrow morphology in patients with collagen vascular disease, and most are limited to systemic lupus erythematosus or rheumatoid arthritis. Objective.-To identify morphologic and immunohistochemical abnormalities specific to each of a wide range of collagen vascular disease cases. Design.-We examined 102 cases of collagen vascular disease and 38 controls and evaluated the complete blood count, peripheral blood morphology, bone marrow morphology, as well as immunohistochemical staining, for numerous cell lineages. Results.-Bone marrow findings, including abnormalities such as lymphoid aggregates, lipogranulomas, or abnormal localization of immature precursors, were not significantly different as compared to the control group. Conclusions.-Bone marrow examination in patients with collagen vascular disease with cytopenias seldom provides new information. Caution should be exercised in interpreting morphologic findings suggestive of myelodysplasiasince these are of a reactive nature in up to 27% of patients with collagen vascular disease. In a cost-effective diagnostic strategy, successful utilization may favor postponing a bone marrow biopsy while a more standardized autoimmune diagnostic panel is being performed. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|