Brief communication: Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait.
ABSTRACT Lactase persistence (LP)-the ability to digest lactose in adulthood-is paradigmatic of Holocenic dietary change affecting the evolutionary trajectory of specific populations. Kuwait represents one location of high LP where the variation in associated genomic regions has not been examined. H...
| Publicado en: | American Journal of Physical Anthropology Vol. 152; no. 1; pp. 140 - 145 |
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| Autores principales: | , , |
| Formato: | Artículo |
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Wiley-Blackwell
Sep2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=89926664&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 89926664 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00029483 APX jtl: American Journal of Physical Anthropology issn: 00029483 maglogo: Y pubinfo: dt: Sep2013 vid: 152 iid: 1 pid: 480 pub: Wiley-Blackwell artinfo: ui: 89926664 10.1002/ajpa.22313 ppf: 140 ppct: 5 formats: tig: atl: Brief communication: Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait. aug: au: Hill, Sarah Catherine Mohammad, Talal Ramadan Kivisild, Toomas affil: Leverhulme Center for Human Evolutionary Studies, University of Cambridge, Cambridge CB2 1QH, UK su: Beta-galactosidase Human genetic variation Gene frequency Lactose Holocene Epoch sug: subj: Dry, Condensed, and Evaporated Dairy Product Manufacturing Butter, cheese, and dry and condensed dairy product manufacturing Beta-galactosidase Human genetic variation Gene frequency Lactose Holocene Epoch keyword: Bedouin genetics lactose tolerance nomadic‐pastoralism nomadic-pastoralism Bedouin genetics lactose tolerance nomadic‐pastoralism nomadic-pastoralism ab: ABSTRACT Lactase persistence (LP)-the ability to digest lactose in adulthood-is paradigmatic of Holocenic dietary change affecting the evolutionary trajectory of specific populations. Kuwait represents one location of high LP where the variation in associated genomic regions has not been examined. Here, we present new sequence data from a 427 bp amplicon 14 kb upstream of the LCT (lactase) gene for two Bedouin tribal populations, the Ajman and Mutran. We estimate the frequency of known LP associated alleles and discuss the impact of nomadic-pastoralism on the associated genetic variation. We observe high frequency (56% on average) of the − 13,915*G allele in both tribes, which is consistent with the high prevalence of LP in Kuwait. Whilst LP associated alleles occur in Kuwait at a similar frequency to other regional populations, we suggest that the − 13,915*G allele frequency among the Kuwaiti Bedouin may be higher than among non-Bedouin Kuwaitis, possibly due to greater historical reliance on milk consumption or genetic drift. Am J Phys Anthropol 152:140-144, 2013. © 2013 Wiley Periodicals, Inc. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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