Plasma Total Antioxidant Capacity (TAC) in Obese Malaysian Subjects.
Introduction: There is a pressing need to better understand the complex biochemical pathways that lead to the pathogenesis of obesity. Increased oxidative stress and decreased antioxidant capacity have been identified to be associated with obesity. Therefore, the objectives of this study were to det...
| Publicado en: | Malaysian Journal of Nutrition Vol. 18; no. 3; pp. 345 - 355 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Nutrition Society of Malaysia
2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=90484099&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 90484099 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1394035X 6CKY jtl: Malaysian Journal of Nutrition issn: 1394035X maglogo: N pubinfo: dt: 2012 vid: 18 iid: 3 pid: 49148 pub: Nutrition Society of Malaysia artinfo: ui: 90484099 90484099 104139026 90484099 ppf: 345 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Plasma Total Antioxidant Capacity (TAC) in Obese Malaysian Subjects. aug: au: Lim SH Fan SH Say YH affil: Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR) Perak Campus, 31900 Kampar, Perak, Malaysia sug: subj: Obesity Physiopathology Antioxidants Oxidative Stress Obesity Blood Human Malaysia Male Female Convenience Sample Questionnaires Interviews Blood Pressure Data Analysis Software Kruskal-Wallis Test Mann-Whitney U Test Funding Source Middle Age Adult Aged Aged, 80 and Over Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Male Female ab: Introduction: There is a pressing need to better understand the complex biochemical pathways that lead to the pathogenesis of obesity. Increased oxidative stress and decreased antioxidant capacity have been identified to be associated with obesity. Therefore, the objectives of this study were to determine the plasma total antioxidant capacity (TAC) levels of Malaysian subjects and to evaluate its potential association with obesity and related anthropometric measurements. Methods: Plasma TAC of 362 multi-ethnic Malaysian subjects from the Kampar Health Clinic (138 males, 224 females; 124 ethnic Malays, 152 Chinese, 86 Indians; 192 non-obese, 170 obese) was measured using Trolox equivalent antioxidant capacity (TEAC) 96-well plate assay. Results: Plasma TAC was significantly lower in obese subjects (M ± SE = 292 ± 10.4 μmol/L) compared to non-obese subjects (397 ± 8.58 μmol/L), whereas it was significantly higher in males and those in the 21-30 age group. Those with salty food preference and practising a strict vegetarian diet also had significantly higher plasma TAC. However, no association was found for other dietary habits (coffee intake) and lifestyle factors (physical activity, smoking). Plasma TAC was also significantly negatively correlated with diastolic blood pressure, waist and hip circumferences, weight, body mass index, total body fat, % subcutaneous fat, visceral fat level, resting metabolism and % skeletal muscle. Conclusion: Plasma TAC was found to be associated with obesity, strict vegetarian practice, salty food preference and all obesity anthropometric indicators, except systolic blood pressure and pulse rate. Obese people have decreased plasma TAC indicating a compromised systemic antioxidant defence and increased oxidative stress. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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