Association between Helicobacter pylori and Serum Leptin in Iranian Dyspeptic Patients.
BACKGROUND To investigate any possible relationship between serum leptin level and H. pylori infection in dyspeptic Iranian adults. METHODS A total of 153 dyspeptic patients referring to Firoozgar hospital for esophagogastroduodenoscopy were enrolled in the study. Serum leptin level was measured bef...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 5; no. 3; pp. 158 - 163 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Jul2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=90496094&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 90496094 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Jul2013 vid: 5 iid: 3 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 90496094 90496094 104233701 90496094 ppf: 158 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Association between Helicobacter pylori and Serum Leptin in Iranian Dyspeptic Patients. aug: au: Hemmasi, Gholamreza Zamani, Farhad Khonsari, Mahmoodreza Sohrabi, Masoudreza Abdollahi, Nafiseh Ajdarkosh, Hossein affil: Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Tehran University of Medical Science, Tehran, Iran sug: subj: Helicobacter Infections Leptin Human Iran Dyspepsia Adult Urease Time Factors Cross Sectional Studies Data Analysis Software T-Tests Mann-Whitney U Test Spearman's Rank Correlation Coefficient Chi Square Test Adult: 19-44 years ab: BACKGROUND To investigate any possible relationship between serum leptin level and H. pylori infection in dyspeptic Iranian adults. METHODS A total of 153 dyspeptic patients referring to Firoozgar hospital for esophagogastroduodenoscopy were enrolled in the study. Serum leptin level was measured before endoscopy, after overnight fasting. Two biopsy specimens were taken from antrum for each patient during endoscopy: one to detect H. pylori infection by Rapid Urease Test (RUT) and the other evaluated by an expert pathologist, blind to the RUT results and patients. Serum leptin level was compared between H. pylori-positive negative groups. RESULTS A total of 153 dyspeptic patients with the mean age of 43.2±14.3 years were evaluated. The overall prevalence of H. pylori infection was 49.6%. H. pylori infection was significantly associated with serum leptin level (p<0.001). In addition, we found a significant relationship between serum leptin level and gender (p<0.02). Furthermore, serum leptin level was correlated with age (r=0.17, p=0.0031). However, the H. pylori -positive group was older in comparison to the H. pylori negative group (45.65±13.9 vs. 40.7±14.13, p=0.035). The two groups were not significantly different in terms of gender, height, weight or BMI. CONCLUSION H. pylori infection may influence leptin production. Advanced age might expose the individual to H. pylori infection and consequently influence the leptin level. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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