Effect of Helicobacter Pylori Eradication on Clinical Symptoms in Gastroesophageal Reflux Disease.
Backgrounds and Objectives: Gastroesophageal reflux disease is one of the most prevalent gastrointestinal disorders and the relationship between GERD and H. pylori is complex and effect of H. pylori eradication on GERD is controversies. The aim of study is to evaluate the effect of H. pylori eradica...
| Publicado en: | Medical Journal of Tabriz University of Medical Sciences & Health Services Vol. 35; no. 3; pp. 54 - 60 |
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| Autores principales: | , , |
| Formato: | abstract research tables/charts Journal Article |
| Publicado: |
Tabriz University of Medical Sciences
Aug/Sep2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=91792824&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 91792824 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16085671 EUW8 jtl: Medical Journal of Tabriz University of Medical Sciences & Health Services issn: 16085671 maglogo: N pubinfo: dt: Aug/Sep2013 vid: 35 iid: 3 pid: 69573 pub: Tabriz University of Medical Sciences artinfo: ui: 91792824 91792824 104154934 91792824 ppf: 54 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Effect of Helicobacter Pylori Eradication on Clinical Symptoms in Gastroesophageal Reflux Disease. aug: au: Somi, Mohammad Hossein Kanani, Parinaz Hossein nezhad, Mohammad ali affil: liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran sug: subj: Helicobacter Pylori Gastroesophageal Reflux Helicobacter Infections Human Dyspepsia Barrett Esophagus Iran ab: Backgrounds and Objectives: Gastroesophageal reflux disease is one of the most prevalent gastrointestinal disorders and the relationship between GERD and H. pylori is complex and effect of H. pylori eradication on GERD is controversies. The aim of study is to evaluate the effect of H. pylori eradication on GERD symptoms. Materials and Methods: In an interventional, before-after study, of 200 patients with chronic dyspepsia and positive H. pylori infection confirmed by rapid urea test or histology and underwent a 2 weeks period of quadruple anti-Helicobacter therapy and a subsequent 6 weeks of pure anti-acid therapy. Eradication's success was assessed based on urea breath test result at least 2 weeks after anti-acid cease, and the second validated symptom questionnaire then was filled out which contained the same questions as the first one. A validated symptom questionnaire about probable symptoms of GERD also filled. Results: GERD's symptoms (Regurgitation, Heart burn) were increased in the eradication group.(heart burn:16% to 32% p=0.03),(regurgitation 13.6% to 15% p=0.04). Retrosternal pain was meaningfully decreased (36% to 29% p=0.04). Wheeze (1.4% to 0.5% p=0.03) and hoarseness (1.5% to 0.6 %p=0.03) had meaningful decrease. Conclusion: H. pylori eradication has variable effect on GERD's symptoms are infected individuals. pubtype: Academic Journal doctype: abstract research tables/charts Journal Article ougenre: Article language: Iranian languages refInfo: holdings: @attributes: islocal: N |
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