An Essential Memory Trace Found.
I argue here that we have succeeded in localizing an essential memory trace for a basic form of associative learning and memory--classical conditioning of discrete responses learned with an aversive stimulus--to the anterior interpositus nucleus of the cerebellum. We first identified the entire esse...
| Published in: | Behavioral Neuroscience Vol. 127; no. 5; pp. 669 - 676 |
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| Format: | Article |
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American Psychological Association
Oct2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=91822926&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 91822926 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: Oct2013 vid: 127 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 91822926 10.1037/a0033978 ppf: 669 ppct: 7 formats: tig: atl: An Essential Memory Trace Found. aug: au: Thompson, Richard F. affil: University of Southern California su: Memory research Brain function localization Associative learning Aversive stimuli Classical conditioning Eyelid conditioning sug: subj: Memory research Brain function localization Associative learning Aversive stimuli Classical conditioning Eyelid conditioning keyword: cerebellum classical conditioning essential memory trace eyelid conditioning interpositus nucleus cerebellum classical conditioning essential memory trace eyelid conditioning interpositus nucleus ab: I argue here that we have succeeded in localizing an essential memory trace for a basic form of associative learning and memory--classical conditioning of discrete responses learned with an aversive stimulus--to the anterior interpositus nucleus of the cerebellum. We first identified the entire essential circuit, using eyelid conditioning as the model system, and used reversible inactivation, during training, of critical structures and pathways to localize definitively the essential memory trace. In recognition of the 30th anniversary of Behavioral Neuroscience, I highlight 1 paper (Tracy, Thompson, Krupa, & Thompson, 1998) that was particularly significant for the progress of this research program. In this review, I present definitive evidence that the essential memory trace for eyelid conditioning is localized to the cerebellum and to no other part of the essential circuit, using electrical stimulation of the pontine nuclei-mossy fibers projecting to the cerebellum as the conditional stimulus (CS; it proved to be a supernormal stimulus resulting in much faster learning than with any peripheral CS) and using an electrical stimulus to the output of the cerebellum as a test, which did not change. Pontine patterns of projection to the cerebellum were confirmed with retrograde labeling techniques. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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