An alarm pheromone increases the responsivity of amygdaline-hippocampal neurons.

The capability to perceive and emit alarm substances, such as 2-hep-tanone, makes animals aware of the presence of danger, leading to some strategies directed towards survival. Strategies of survival involve emotional memory which is processed by deep temporal lobe structures, such as amygdaloid com...

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Publicado en:Salud Mental Vol. 36; no. 4; pp. 279 - 285
Autores principales: Molina-Jiménez, Tania, Gutiérrez-García, Ana G., Contreras, Carlos M.
Formato: Artículo
Publicado: Instituto Nacional de Psiquiatria Ramon de la Fuente jul/ago2013
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Acceso en línea:Ver este registro en EBSCOhost
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      dt: jul/ago2013
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        10.17711/SM.0185-3325.2013.034
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        atl: An alarm pheromone increases the responsivity of amygdaline-hippocampal neurons.
      aug:
        au:
          Molina-Jiménez, Tania
          Gutiérrez-García, Ana G.
          Contreras, Carlos M.
        affil:
          Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, México
          Facultad de Psicología, Universidad Veracruzana, Xalapa Veracruz, México
          Unidad Periférica del Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. Xalapa, Veracruz, México
      su:
        Pheromones
        Hormones
        Neurons
        Sensory perception
        Amygdaloid body
        Hippocampus (Brain)
        Brain function localization
        Memory research
      sug:
        subj:
          Pheromones
          Hormones
          Neurons
          Sensory perception
          Amygdaloid body
          Hippocampus (Brain)
          Brain function localization
          Memory research
      keyword:
        2-heptanone
        alarm pheromone
        anxiety
        emotional memory
        hippocampus
        medial amygdala
        2-heptanona
        amígdala medial
        ansiedad
        feromona de alarma
        hipocampo
        memoria emocional
      ab:
        The capability to perceive and emit alarm substances, such as 2-hep-tanone, makes animals aware of the presence of danger, leading to some strategies directed towards survival. Strategies of survival involve emotional memory which is processed by deep temporal lobe structures, such as amygdaloid complex and hippocampus. In the Wi-star rat, 2-heptanone produces anxiety-like behavior and an increased firing rate of basal amygdaline neurons. However, it is unknown whether 2-heptanone modifies the responsivity of medial amygdaline-hippocampal connection. Therefore, we placed a group (n=10) of Wistar rats in a plexiglass cage impregnated with 2-heptanone. Rats from control group (n=10) were introduced into a similar clean cage. Twenty four hours later we obtained single-unit extracellular recordings from the hippocampus (CA1-CA3) neurons identified by their connection to medial amygdala. Although the basal neuronal firing rate was similar between groups, first order interval distribution histogram analysis showed that 2-heptanone produced shorter intervals of firing rate. Peristimulus histograms indicated that: i) the amygdaline stimulation produces an increased firing rate in hippocampal neurons; and ii) this response is increased and enlarged on the 2-heptanone group. Since a single exposure to an alarm pheromone seems to facilitate the amygdala-hippocampal connection, results suggest the initial formation of contextual memories related with fear.
        La percepción olfatoria de feromonas de alarma, como la 2-hepta-nona, promueve ciertas estrategias de supervivencia con la participación de la memoria emocional, integrada en estructuras del lóbulo temporal, como la amígdala y el hipocampo. En la rata Wistar, la olfacción de 2-heptanona genera conductas sugerentes de ansiedad y un incremento de la tasa de disparo neuronal del núcleo basal de la amígdala. Sin embargo, no se conoce si la 2-heptanona modifica la respon5¡vidad de la conexión amígdala medial-hipocampo. Un grupo de ratas Wistar (n=10) fue colocado dentro de una caja de acrílico impregnada con 2-heptanona; el grupo control (n=10) fue introducido en una caja limpia. Veinticuatro horas después se obtuvo el registro unitario extracelular de neuronas del hipocampo (CA1-CA3) identificadas por su conexión con la amígdala medial. Aunque la tasa de disparo basal fue similar entre los grupos experimentales, el hisfogra-ma de distribución de intervalos de primer orden indicó un predominio de intervalos de breve duración en el grupo 2-heptanona. Los histogramas periestímulo indicaron que: i) las neuronas hipocampales responden con un incremento en la tasa de disparo neuronal ante la estimulación amigdalina; ii) la respuesta es de mayor magnitud y duración en el grupo previamente expuesto a 2-heptanona. Dado que una sola exposición a una feromona de alarma facilita la conexión amígdala medial-hipocampo, los resultados sugieren la formación inicial de una memoria contextual relacionada con el miedo.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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      holder: Instituto Nacional de Psiquiatria Ramon de la Fuente
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