Reconciliation of Chemical, Enzymatic, Spectroscopic and Computational Data To Assign the Absolute Configuration of the DNA Base Lesion Spiroiminodihydantoin.

The diastereomeric spiroiminodihydantoin-2'-deoxyribonucleoside (dSp) lesions resulting from 2'-deoxyguanosine (dG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) oxidation have generated much attention due to their highly mutagenic nature. Their propeller-like shape leads these molecules to display m...

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Publicado en:	Journal of the American Chemical Society Vol. 135; no. 48; pp. 18191 - 18205
Autores principales:	Fleming, Aaron M., Orendt, Anita M., Yanan He, Zhu, Judy, Dukor, Rina K., Burrows, Cynthia J.
Formato:	Artículo
Publicado:	American Chemical Society 12/4/2013
Materias:	Deoxyribonucleotides Deoxyguanosine Oxidation Circular dichroism Isomers Density functional theory DNA damage
Acceso en línea:	Ver este registro en EBSCOhost