Frequency of Upgrading to Carcinoma at Final Excision in Biopsy-Diagnosed Benign Papillary Lesions of the Breast.

Purpose: To determine the frequency of carcinoma in final resections of biopsy-diagnosed benign papillary breast lesions and to determine the radiological and pathological features associated with increased likelihood of carcinoma. Methods: Hospital pathology records were searched for biopsies of be...

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Publicado en:Canadian Journal of Pathology Vol. 5; no. 3; pp. 89 - 96
Autores principales: Petkiewicz, Stephanie, Islam, Shahidul
Formato: Journal Article
Publicado: Canadian Association of Pathologists Fall2013
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Fall2013
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      pub: Canadian Association of Pathologists
      place: Kingston, Ontario
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        atl: Frequency of Upgrading to Carcinoma at Final Excision in Biopsy-Diagnosed Benign Papillary Lesions of the Breast.
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        au:
          Petkiewicz, Stephanie
          Islam, Shahidul
        affil: Members of the Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa Hospital, in Ottawa, Ontario
      sug:
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        Purpose: To determine the frequency of carcinoma in final resections of biopsy-diagnosed benign papillary breast lesions and to determine the radiological and pathological features associated with increased likelihood of carcinoma. Methods: Hospital pathology records were searched for biopsies of benign papillary lesions of the breast with subsequent excisions. Radiological and histological characteristics that may have increased suspicion of carcinoma were sought. Histopathological sections from the biopsy and resection material were examined for features suggestive of underlying malignancy. Results: Of the 41 biopsy-diagnosed papillary lesions, 41% harboured malignancy at final excision. Ductal carcinoma in situ was the most common finding, but invasive carcinoma was also diagnosed. Lesion size was significantly associated with risk of malignancy. Re-examination of the histological sections confirmed that in most cases the carcinoma was not present within the biopsy material. Conclusion: At our institution, 41% of biopsy-diagnosed papillary lesions of the breast were malignant at resection, larger lesions being at greater risk. Our data indicate that the most common cause of this discrepancy is sampling error (with carcinoma not present within the biopsy material). This suggests that women diagnosed with papillary lesions on biopsy should undergo local resection.
        But: Établir la frequence du carcinome papillaire du sein dans des tissus mammaires excises en raison de la presence de lesions papillaires bénignes détectées a la biopsie et determiner les traits radiologiques et pathologiques laissant entrevoir une probabilité accrue de carcinome. Méthodologie: Recherche de cas de lesions papillaires bénignes du sein détectées á la biopsie et excisées dans des dossiers du service de pathologie; relevé des caractéristiques radiologiques et histologiques pouvant étayer la suspicion de carcinome; examen des coupes histologiques du tissu prélevé á la biopsie et du tissu excise en vue de cerner des traits indicateurs d'une tumeur maligne. Résultats: Dans une proportion de 41 % des 41 cas de lésions papillaires détectées a la biopsie que nous avons recensés, une tumeur maligne est présente dans le tissu excise. Le carcinome canalaire in situ est le plus courant, quoiqu'il y ait des cas de carcinome invasif. La taille de la lesion est un indicateur prévisionnel important du risque de malignité. Le réexamen des coupes histologiques confirme que, dans la plupart des cas, le carcinome est absent dans le tissu prélevé a la biopsie. Conclusion: Á notre établissement, une tumeur maligne est présente dans le tissu mammaire excise de 41 % des cas de lesions papillaires du sein détectées a la biopsie, les lesions les plus grandes posant le plus grand risque de malignité. Selon nos données, la disparité des diagnostics tient a une erreur de prélévement (carcinome absent dans le tissu prélevé á la biopsie). En conclusion, la resection locale est indiquée en presence de lesions papillaires du sein détectées a la biopsie.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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