Urinary Polycyclic Aromatic Hydrocarbons and Childhood Obesity: NHANES (2001-2006).
Background: Polycyclic aromatic hydrocarbons (PAHs) are known carcinogens and suspected endocrine disruptors. Prenatal exposure to PAHs has been associated with obesity in early childhood. Objective: We examined the association of urinary PAH metabolites with adiposity outcomes [body mass index (BM...
| Publicado en: | Environmental Health Perspectives Vol. 122; no. 3; pp. 299 - 304 |
|---|---|
| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Mar2014
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=94758239&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 94758239 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Mar2014 vid: 122 iid: 3 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 94758239 104041695 104041695 10.1289/ehp.1307234 94758239 ppf: 299 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Urinary Polycyclic Aromatic Hydrocarbons and Childhood Obesity: NHANES (2001-2006). aug: au: Scinicariello, Franco Buser, Melanie C. affil: Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, Georgia, USA sug: subj: Hydrocarbons, Aromatic Urine Pediatric Obesity Etiology Human Child Adolescence Regression Body Mass Index Waist Circumference Young Adult Age Factors United States Odds Ratio Descriptive Statistics Male Female C-Reactive Protein Blood Data Analysis Software Confidence Intervals Funding Source Child: 6-12 years Adolescent: 13-18 years Male Female ab: Background: Polycyclic aromatic hydrocarbons (PAHs) are known carcinogens and suspected endocrine disruptors. Prenatal exposure to PAHs has been associated with obesity in early childhood. Objective: We examined the association of urinary PAH metabolites with adiposity outcomes [body mass index (BMI) z-score, waist circumference (WC), and rate of obesity] in children and adolescents. Methods: We performed whole-sample analyses of 3,189 individuals 6-19 years of age who participated in the 2001-2006 National Health and Nutrition Examination Survey. We performed multivariate linear and logistic regression to analyze the association of BMI z-score, WC, and obesity with concentrations of single urinary PAH compounds and the sum of PAHs. Furthermore, the analyses were stratified by developmental stage [i.e., children (6-11 years) and adolescents (12-19 years)]. Results: BMI z-score, WC, and obesity were positively associated with the molecular mass sum of the PAHs and the total sum of naphthalene metabolites. Most associations increased monotonically with increasing quartiles of exposure among children 6-11 years of age, whereas dose-response trends were less consistent for adolescents (12-19 years of age). Neither total PAHs nor total naphthalene metabolites were associated with overweight in either age group, and there was little evidence of associations between the outcomes and individual PAHs. Conclusions: Total urinary PAH metabolites and naphthalene metabolites were associated with higher BMI, WC, and obesity in children 6-11 years of age, with positive but less consistent associations among adolescents. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|