VEGF and bFGF Expression and Histological Characteristics of the Bone-Tendon Junction during Acute Injury Healing.
Bone-tendon junction (BTJ) injuries are common and may be caused by acute trauma and delayed healing during exercise or work. To understand the nature of the healing process of BTJ injuries would help to prevent injuries and improve treatment. Thirty-three mature female rabbit hindlimbs were assigne...
| Publicado en: | Journal of Sports Science & Medicine Vol. 13; no. 1; pp. 15 - 22 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Hakan Gur, Journal of Sports Science & Medicine
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=94883562&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 94883562 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13032968 FYN jtl: Journal of Sports Science & Medicine issn: 13032968 maglogo: N pubinfo: dt: 2014 vid: 13 iid: 1 pid: 26030 pub: Hakan Gur, Journal of Sports Science & Medicine artinfo: ui: 94883562 94883562 104044505 94883562 ppf: 15 ppct: 7 formats: fmt: @attributes: type: P tig: atl: VEGF and bFGF Expression and Histological Characteristics of the Bone-Tendon Junction during Acute Injury Healing. aug: au: Lin Wang Weiwei Gao Kaiyu Xiong Kuan Hu Xincun Liu Hui He affil: Section of Sports Medicine, Beijing Sport University, Beijing, China sug: subj: Bone and Bones Injuries Tendon Injuries Wound Healing China Funding Source Animal Studies In Vivo Studies Rabbits Sports Science Histological Techniques Fibroblasts Growth Substances Metabolism Vascular Endothelial Growth Factors Metabolism Descriptive Statistics Immunohistochemistry One-Way Analysis of Variance Data Analysis Software ab: Bone-tendon junction (BTJ) injuries are common and may be caused by acute trauma and delayed healing during exercise or work. To understand the nature of the healing process of BTJ injuries would help to prevent injuries and improve treatment. Thirty-three mature female rabbit hindlimbs were assigned to normal control (CON, n = 7) and injury groups (n = 26). The acute injury was established by administering one 7 plumblossom needle puncture. Specimens were harvested post injury at 1, 2, 4, and 8 weeks (ND1W, n = 6; ND2W, n = 6; ND4W, n = 7; and ND8W, n = 7). The injury existed in all of the injury groups. Compared with the CON group, all of the animals in the injury group showed poor cell profiles, an unclear or undetectable tide mark, a proteoglycan area and profile changes; the BTJ cell density diminished significantly in the ND1W (p < 0.01), ND2W (p < 0.05), ND4W (p < 0.01), and ND8W groups (p < 0.01); the fibrocartilage zone thickness in all injury groups was significantly thicker than in the CON group (p < 0.05), but no significant difference was found among the injury groups (p>0.05). The basic fibroblast growth factor (bFGF) expression in the CON group was significantly less than in the ND1W group (p<0.01), but no significant difference was found when compared with the ND2W, ND4W, and ND8W groups. The bFGF expression in the ND1W group was higher than that of the ND4W (p < 0.05) and ND8W groups (p < 0.01). The vascular endothelial growth factor (VEGF) levels were not significantly different among the groups (p > 0.05). The bFGF and VEGF expression levels indicated that the healing process stopped at 8 weeks post injury or was not activated, although the injury had not healed by histological examination. A repeatable animal model of BTJ acute injury was established in this study, and the results described the BTJ acute injury healing difficult concerned with the repairing stop. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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