Association of Single-Nucleotide Polymorphisms in a Metabotropic Glutamate Receptor GRM3 Gene Subunit to Alcohol-Dependent Male Subjects.
Aims: The purpose of this study was to investigate the association between the metabotropic glutamate receptor 3 (GRM3) subunit gene and alcohol dependence by the single-nucleotide polymorphisms (SNPs). Methods: Two hundred and forty-eight male alcohol-dependent patients and 235 male control subject...
| Publicado en: | Alcohol & Alcoholism Vol. 49; no. 3; pp. 256 - 261 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
May/Jun2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=95756029&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 95756029 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: May/Jun2014 vid: 49 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 95756029 103937664 103937664 10.1093/alcalc/agu004 95756029 ppf: 256 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Association of Single-Nucleotide Polymorphisms in a Metabotropic Glutamate Receptor GRM3 Gene Subunit to Alcohol-Dependent Male Subjects. aug: au: Xia, Yan Wu, Zheng Ma, Dongying Tang, Chunling Liu, Lei Xin, Feng Zhu, Daling Hu, Jian affil: Mental Health Institute , Harbin Medical University, Mental Health Centre, 1st Affiliated Hospital of Harbin Medical University , 23 Youzheng Street, Harbin, Heilongjiang Province 150001 , PR China sug: subj: Alcoholism Familial and Genetic Polymorphism, Genetic Male Funding Source Chi Square Test Utilization Odds Ratio Utilization Confidence Intervals Utilization Genotype Adult Middle Age T-Tests Utilization China Human Academic Medical Centers Adult: 19-44 years Middle Aged: 45-64 years Male ab: Aims: The purpose of this study was to investigate the association between the metabotropic glutamate receptor 3 (GRM3) subunit gene and alcohol dependence by the single-nucleotide polymorphisms (SNPs). Methods: Two hundred and forty-eight male alcohol-dependent patients and 235 male control subjects were recruited. Ten SNPs in the GRM3 region were studied, and genotyping of SNPs was performed by ligase detection reactions. Results: We found highly significant differences in allele and genotype frequencies of rs6465084 between the alcohol-dependent and control group, with the greater frequency of A allele of SNP rs6465084 in alcohol-dependent group. We also found significant differences of haplotype frequencies in five combinations (including TAATATT, CAGTATT, TCGTATT, CAATAGC, TAATATC) in the linkage disequilibrium constructed by seven SNPs between the groups. Conclusion: Our results supplied the first evidence that the polymorphism of GRM3 gene associates with the morbidity of alcohol dependence in human being, which may support a new potential target for alcoholism treatment. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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