Helicobacter Pylori and non-Malignant Haematological Disorders in Adults.
Background: Helicobacter pylori infects half of world's population causing local tissue damage in gastric mucosa. The implication in a variety of extraintestinal disorders is less clear and the available studies often lead to conflicting results. Aim: This article will review the implication of Heli...
| Publicado en: | International Journal of Caring Sciences Vol. 7; no. 2; pp. 353 - 362 |
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| Autores principales: | , |
| Formato: | review tables/charts Journal Article |
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International Journal of Caring Sciences
May-Aug2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=96010967&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 96010967 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17915201 B92O jtl: International Journal of Caring Sciences issn: 17915201 maglogo: N pubinfo: dt: May-Aug2014 vid: 7 iid: 2 pid: 64496 pub: International Journal of Caring Sciences artinfo: ui: 96010967 96010967 103945298 96010967 ppf: 353 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Helicobacter Pylori and non-Malignant Haematological Disorders in Adults. aug: au: Kyriazi, Vasiliki Tachtsi, Maria affil: Department of Clinical Hematology, Lincoln County Hospital, National Health Service (NHS), Lincoln, United Kingdom sug: subj: Helicobacter Pylori Helicobacter Infections Complications Hematologic Diseases Risk Factors Adult PubMed Hematologic Diseases Physiopathology Helicobacter Infections Physiopathology Anemia, Iron Deficiency Thrombocytopenia Thrombosis Adult: 19-44 years ab: Background: Helicobacter pylori infects half of world's population causing local tissue damage in gastric mucosa. The implication in a variety of extraintestinal disorders is less clear and the available studies often lead to conflicting results. Aim: This article will review the implication of Helicobacter pylori in the development of non-malignant haematological disorders in adults. Epidemiological data, possible pathogenetic mechanisms and the role of eradication therapy are analyzed. Methodology: Relevant articles published in English during the last two decades were found through PubMed and SCOPUS. Results: Significant advances have been made in understanding the pathophysiology of Helicobacter pylori-induced haematological disorders. The investigation of persistently thrombocytopenic and anaemic patients in absence of other causative factors should include Helicobacter pylori assays. Half of infected thrombocytopenic patients respond to eradication, whereas the outcomes are less clear in anaemic disorders. Bacterial strains and genetic factors seem to influence the outcome of bacterium eradication. The implication of Helicobacter pylori in atherosclerosis remains controversial and it is attributed either to inflammation process or to direct alteration in haemostatic factors. Conclusion: Large randomized studies are needed to determine the subpopulation at risk of developing Helicobacter pylori-related haematological disorders. In this case prompt screening and eradication treatment could be of major importance. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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