L-Selenomethionine Does Not Protect Against Testosterone Plus 17β-Estradiol-Induced Oxidative Stress and Preneoplastic Lesions in the Prostate of NBL Rats.
Previous animal studies examining dietary selenium effects on prostatic carcinogenesis did not show preventive benefit, including 1 study in a rat model involving testosterone (T) and estradiol (E2)-induced prostatic oxidative stress. Here, we examined modulation of T + E2-induced prostatic oxidativ...
| Publicado en: | Nutrition & Cancer Vol. 66; no. 5; pp. 825 - 835 |
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| Autores principales: | , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jul2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=96673000&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 96673000 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Jul2014 vid: 66 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 96673000 103962773 103962773 10.1080/01635581.2014.904907 96673000 ppf: 825 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: L-Selenomethionine Does Not Protect Against Testosterone Plus 17β-Estradiol-Induced Oxidative Stress and Preneoplastic Lesions in the Prostate of NBL Rats. aug: au: Özten, Nur Schlicht, Michael Diamond, Alan M. Bosland, Maarten C. affil: University of Illinois at Chicago, School of Medicine, Department of Pathology, Chicago, Illinois, USA sug: subj: Precancerous Conditions Prostate Oxidative Stress Animal Studies Rats Male Illinois Academic Medical Centers Immunohistochemistry Utilization Prostatic Neoplasms Epidemiology Selenium Blotting, Western Utilization Fisher's Exact Test Utilization Chi Square Test Utilization Mann-Whitney U Test Utilization Kruskal-Wallis Test Utilization Post Hoc Analysis Utilization Analysis of Variance Utilization Funding Source Male ab: Previous animal studies examining dietary selenium effects on prostatic carcinogenesis did not show preventive benefit, including 1 study in a rat model involving testosterone (T) and estradiol (E2)-induced prostatic oxidative stress. Here, we examined modulation of T + E2-induced prostatic oxidative stress, dysplasia, and inflammation by L-selenomethionine at 1.5 or 3.0 mg selenium/kg in NIH-07 diet in Noble (Nbl)/Crl rats treated with T + E2 for 16 wk. Hormone treatment increased immunohistochemical staining for 8-hydroxydeoxyguanosine (8-OHdG) in the prostatic sites of T + E2-induced preneoplasia (P< 0.05), but selenomethionine did not attenuate 8-OHdG staining and dysplasia in the lateral prostate. Glutathione-peroxidase activity (P< 0.05) and mRNA expression were induced by T + E2 (P< 0.0001) but not changed by selenomethionine. Selenomethionine did not cause significant responses in expression and activity of glutathione-peroxidase and MnSOD, except for a reduction of MnSOD protein expression in the lateral prostate (P< 0.01). The absence of reduction of oxidative stress and dysplasia and the minimal effects on antioxidant enzymes caused by selenomethionine are consistent with the null effects observed in selenium supplementation animal studies and clinical trials. Significant (P< 0.01) opposite apoptosis/cell proliferation balance responses to selenomethionine and to T + E2 occurred in the lateral and dorsal prostate, explaining why T + E2 induces lesions selectively in the lateral lobe of NBL rats. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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