Active Relearning for Robust Supervised Training of Emphysema Patterns.

Radiologists are adept at recognizing the character and extent of lung parenchymal abnormalities in computed tomography (CT) scans. However, the inconsistent differential diagnosis due to subjective aggregation necessitates the exploration of automated classification based on supervised or unsupervi...

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Publicado en:Journal of Digital Imaging Vol. 27; no. 4; pp. 548 - 556
Autores principales: Raghunath, Sushravya, Rajagopalan, Srinivasan, Karwoski, Ronald, Bartholmai, Brian, Robb, Richard
Formato: diagnostic images equations & formulas tables/charts Journal Article
Publicado: Springer Nature Aug2014
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2014
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      pub: Springer Nature
      place: New York, New York
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        atl: Active Relearning for Robust Supervised Training of Emphysema Patterns.
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        au:
          Raghunath, Sushravya
          Rajagopalan, Srinivasan
          Karwoski, Ronald
          Bartholmai, Brian
          Robb, Richard
        affil: Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW Rochester 55905 USA
      sug:
        subj:
          Tomography, X-Ray Computed
          Radiographic Image Interpretation, Computer-Assisted
          Emphysema Classification
          Feedback
          Severity of Illness
      ab: Radiologists are adept at recognizing the character and extent of lung parenchymal abnormalities in computed tomography (CT) scans. However, the inconsistent differential diagnosis due to subjective aggregation necessitates the exploration of automated classification based on supervised or unsupervised learning. The robustness of supervised learning depends on the training samples. Towards optimizing emphysema classification, we introduce a physician- in- the- loop feedback approach to minimize ambiguity in the selected training samples. An experienced thoracic radiologist selected 412 regions of interest (ROIs) across 15 datasets to represent 124, 129, 139 and 20 training samples of mild, moderate, severe emphysema and normal appearance, respectively. Using multi-view (multiple metrics to capture complementary features) inductive learning, an ensemble of seven un-optimized support vector models (SVM) each based on a specific metric was constructed in less than 6 s. The training samples were classified using seven SVM models and consensus labels were created using majority voting. In the active relearning phase, the ensemble- expert label conflicts were resolved by the expert. The efficacy and generality of active relearning feedback was assessed in the optimized parameter space of six general purpose classifiers across the seven dissimilarity metrics. The proposed just- in- time active relearning feedback with un-optimized SVMs yielded 15 % increase in classification accuracy and 25 % reduction in the number of support vectors. The average improvement in accuracy of six classifiers in their optimized parameter space was 21 %. The proposed cooperative feedback method enhances the quality of training samples used to construct automated classification of emphysematous CT scans. Such an approach could lead to substantial improvement in quantification of emphysema.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
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        Journal Article
      ougenre: Article
    language: English
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