Metallothionein Lower Under-Expression in Benign Tumors than That in Malignant Tumors: Systematic Review Article and Meta-Analysis.
Background: Metallothionein (MT) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. A meta-analysis was conducted to evaluate comprehensively the MT expression difference in various benign tu...
| Publicado en: | Iranian Journal of Public Health Vol. 43; no. 6; pp. 696 - 705 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Tehran University of Medical Sciences
Jun2014
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=97028722&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 97028722 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22516085 6N6F jtl: Iranian Journal of Public Health issn: 22516085 maglogo: N pubinfo: dt: Jun2014 vid: 43 iid: 6 pid: 21783 pub: Tehran University of Medical Sciences artinfo: ui: 97028722 97028722 103974767 97028722 ppf: 696 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Metallothionein Lower Under-Expression in Benign Tumors than That in Malignant Tumors: Systematic Review Article and Meta-Analysis. aug: au: Jie ZHANG Ruijie SUN Yue LIU Guinian WANG Qinglu WANG affil: Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College, Zibo, China sug: subj: Biological Markers Analysis Proteins Analysis Neoplasms Analysis Funding Source Human Meta Analysis Systematic Review Descriptive Statistics Odds Ratio Confidence Intervals P-Value ab: Background: Metallothionein (MT) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. A meta-analysis was conducted to evaluate comprehensively the MT expression difference in various benign tumors and malignant tumors, which compared the high with low MT expression levels in patients of the available studies. Finally, a total of 13 studies dealing with various tumors were involved for this meta-analysis. The results indicated that lower expression of MT in various benign tumors tissue than that in corresponding malignant tumors with the pooled OR of 0.52 (95 % CI 0.18-1.47, P ＜0.001). In conclusion, MT expression difference is associated with tumor various stages in tumor patients and could be a useful clinical criteria of distinguishing benign tumors and malignant tumors for those patients. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|