Mammilliothalamic Tract Lesions Disrupt Tests of Visuo-Spatial Memory.
The mammillary bodies and their projections via the mammilliothalamic tract to the anterior thalamic nuclei are known to be important for spatial memory in rodents, but their precise role remains unclear. To determine whether transection of the mammilliothalamic tract can produce deficits on tests o...
| Publicado en: | Behavioral Neuroscience Vol. 128; no. 4; pp. 494 - 504 |
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| Autores principales: | , |
| Formato: | Artículo |
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American Psychological Association
Aug2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=97347939&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 97347939 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: Aug2014 vid: 128 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 97347939 10.1037/bne0000001 ppf: 494 ppct: 10 formats: tig: atl: Mammilliothalamic Tract Lesions Disrupt Tests of Visuo-Spatial Memory. aug: au: Nelson, Andrew J. D. Vann, Seralynne D. affil: Cardiff University su: Thalamic nuclei Spatial memory Laboratory rodents Object recognition algorithms Geniculate bodies sug: subj: All other miscellaneous animal production Thalamic nuclei Spatial memory Laboratory rodents Object recognition algorithms Geniculate bodies keyword: anterior thalamic nucleus mammillary bodies mammilliothalamic tract recognition memory spatial memory anterior thalamic nucleus mammillary bodies mammilliothalamic tract recognition memory spatial memory ab: The mammillary bodies and their projections via the mammilliothalamic tract to the anterior thalamic nuclei are known to be important for spatial memory in rodents, but their precise role remains unclear. To determine whether transection of the mammilliothalamic tract can produce deficits on tests of spatial memory even when the navigational demands placed on the animal are limited, rats with discrete mammilliothalamic tract lesions were tested on the ability to use distal visual cues to discriminate between 2 locations within a room, irrespective of the direction traveled (Experiment 1). Animals with mammilliothalamic tract lesions acquired this task more slowly and less accurately than control animals. Consistent with this impairment in discriminating different spatial locations, the same lesions also severely disrupted object-in-place memory but spared performance on standard tests of object recognition memory (Experiment 2). Finally, to compare performance on a task that is known to be sensitive to mammilliothalamic transection and requires animals to actively navigate within their environment, the effect of the lesions on spatial working memory in the radial-arm maze was examined. Taken together, the results suggest that even when there are little or no navigational demands, mammilliothalamic tract damage still results in impoverished encoding of spatial location pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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